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Pteropine Orthoreovirus in an Angolan Soft-Furred Fruit Bat (Lissonycteris angolensis) in Uganda Dramatically Expands the Global Distribution of an Emerging Bat-Borne Respiratory Virus

1
Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA
2
Global Health Institute, University of Wisconsin-Madison, Madison, WI 53706, USA
*
Author to whom correspondence should be addressed.
Viruses 2020, 12(7), 740; https://doi.org/10.3390/v12070740
Received: 2 June 2020 / Revised: 2 July 2020 / Accepted: 7 July 2020 / Published: 9 July 2020
(This article belongs to the Section Animal Viruses)
Pteropine orthoreovirus (PRV; Reoviridae: Spinareovirinae) is an emerging bat-borne zoonotic virus that causes influenza-like illness (ILI). PRV has thus far been found only in Australia and Asia, where diverse old-world fruit bats (Pteropodidae) serve as hosts. In this study, we report the discovery of PRV in Africa, in an Angolan soft-furred fruit bat (Lissonycteris angolensis ruwenzorii) from Bundibugyo District, Uganda. Metagenomic characterization of a rectal swab yielded 10 dsRNA genome segments, revealing this virus to cluster within the known diversity of PRV variants detected in bats and humans in Southeast Asia. Phylogeographic analyses revealed a correlation between geographic distance and genetic divergence of PRVs globally, which suggests a geographic continuum of PRV diversity spanning Southeast Asia to sub-Saharan Africa. The discovery of PRV in an African bat dramatically expands the geographic range of this zoonotic virus and warrants further surveillance for PRVs outside of Southeast Asia. View Full-Text
Keywords: pteropine orthoreovirus; bats; reoviridae; emerging respiratory infections pteropine orthoreovirus; bats; reoviridae; emerging respiratory infections
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MDPI and ACS Style

Bennett, A.J.; Goldberg, T.L. Pteropine Orthoreovirus in an Angolan Soft-Furred Fruit Bat (Lissonycteris angolensis) in Uganda Dramatically Expands the Global Distribution of an Emerging Bat-Borne Respiratory Virus. Viruses 2020, 12, 740. https://doi.org/10.3390/v12070740

AMA Style

Bennett AJ, Goldberg TL. Pteropine Orthoreovirus in an Angolan Soft-Furred Fruit Bat (Lissonycteris angolensis) in Uganda Dramatically Expands the Global Distribution of an Emerging Bat-Borne Respiratory Virus. Viruses. 2020; 12(7):740. https://doi.org/10.3390/v12070740

Chicago/Turabian Style

Bennett, Andrew J., and Tony L. Goldberg. 2020. "Pteropine Orthoreovirus in an Angolan Soft-Furred Fruit Bat (Lissonycteris angolensis) in Uganda Dramatically Expands the Global Distribution of an Emerging Bat-Borne Respiratory Virus" Viruses 12, no. 7: 740. https://doi.org/10.3390/v12070740

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