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Open AccessReview

Host Protective Immune Responses against Influenza A Virus Infection

by Hi Eun Jung 1,* and Heung Kyu Lee 1,2,*
Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea
KAIST Institute for Health Science and Technology, KAIST, Daejeon 34141, Korea
Authors to whom correspondence should be addressed.
Viruses 2020, 12(5), 504;
Received: 7 March 2020 / Revised: 27 April 2020 / Accepted: 30 April 2020 / Published: 3 May 2020
(This article belongs to the Special Issue Influenza A Virus: Host-Virus Relationship)
Influenza viruses cause infectious respiratory disease characterized by fever, myalgia, and congestion, ranging in severity from mild to life-threating. Although enormous efforts have aimed to prevent and treat influenza infections, seasonal and pandemic influenza outbreaks remain a major public health concern. This is largely because influenza viruses rapidly undergo genetic mutations that restrict the long-lasting efficacy of vaccine-induced immune responses and therapeutic regimens. In this review, we discuss the virological features of influenza A viruses and provide an overview of current knowledge of the innate sensing of invading influenza viruses and the protective immune responses in the host. View Full-Text
Keywords: influenza virus; anti-influenza immune responses influenza virus; anti-influenza immune responses
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Jung, H.E.; Lee, H.K. Host Protective Immune Responses against Influenza A Virus Infection. Viruses 2020, 12, 504.

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