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Open AccessArticle

Rabies in the African Civet: An Incidental Host for Lyssaviruses?

1
Agricultural Research Council, Onderstepoort Veterinary Institute, OIE Rabies Reference Laboratory, Pretoria 0110, South Africa
2
Department of Veterinary Tropical Diseases, University of Pretoria, Faculty of Veterinary Sciences, Onderstepoort, Pretoria 0110, South Africa
3
OIE Rabies Reference Laboratory, Wildlife Zoonoses and Vector Borne Diseases Research Group, Animal and Plant Health Agency (APHA, Weybridge), Surrey KT15 3NB, UK
4
Institute of Infection and Global Health, University of Liverpool, Liverpool L7 3EA, UK
5
School of Veterinary Medicine, University of Surrey, Guildford GU2 7XH, UK
6
Faculty of Health and Life Sciences, University of Liverpool, Liverpool L69 3GB, UK
7
Institute for Infection and Immunity, St. George’s University of London, London SW17 0RE, UK
*
Author to whom correspondence should be addressed.
Viruses 2020, 12(4), 368; https://doi.org/10.3390/v12040368
Received: 31 August 2019 / Revised: 10 March 2020 / Accepted: 11 March 2020 / Published: 27 March 2020
(This article belongs to the Special Issue Rabies Virus: Knowledge Gaps and Challenges to Elimination)
In South Africa, canid rabies virus (RABV) infection is maintained in domestic and wildlife species. The identification of rabies in African civets raised the question of whether this wildlife carnivore is a potential reservoir host of RABVs of direct and ancestral dog origin (dog-maintained and dog-derived origins) with an independent cycle of transmission. Genetic analyses of African civet nucleoprotein sequences for 23 African civet RABVs and historically published sequences demonstrated that RABVs from African civets have two origins related to dog and mongoose rabies enzootics. The data support observations of the interaction of civets with domestic dogs and wildlife mongooses, mostly in Northern South Africa and North-East Zimbabwe. Within each host species clade, African civet RABVs group exclusively together, implying intra-species virus transfer occurs readily. The canid RABV clade appears to support virus transfer more readily between hosts than mongoose RABVs. Furthermore, these data probably indicate short transmission chains with conspecifics that may be related to transient rabies maintenance in African civets. Hence, it is important to continue monitoring the emergence of lyssaviruses in this host. Observations from this study are supported by ongoing and independent similar cases, in which bat-eared foxes and black-backed jackal species maintain independent rabies cycles of what were once dog-maintained RABVs. View Full-Text
Keywords: rabies virus; African civet; incidental host rabies virus; African civet; incidental host
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Sabeta, C.T.; Marston, D.A.; McElhinney, L.M.; Horton, D.L.; Phahladira, B.M.N.; Fooks, A.R. Rabies in the African Civet: An Incidental Host for Lyssaviruses? Viruses 2020, 12, 368.

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