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Viruses
Volume 12
Issue 2
10.3390/v12020187
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Article

Antibody-Mediated Porcine Reproductive and Respiratory Syndrome Virus Infection Downregulates the Production of Interferon-α and Tumor Necrosis Factor-α in Porcine Alveolar Macrophages via Fc Gamma Receptor I and III

by
Liujun Zhang
,
Wen Li
,
Yangyang Sun
,
Linghao Kong
,
Pengli Xu
,
Pingan Xia
* and
Gaiping Zhang
College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, China
*
Author to whom correspondence should be addressed.
Viruses 2020, 12(2), 187; https://doi.org/10.3390/v12020187
Received: 15 January 2020 / Revised: 1 February 2020 / Accepted: 6 February 2020 / Published: 8 February 2020
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Abstract

Antibody-dependent enhancement (ADE) contributes to the pathogenesis of porcine reproductive and respiratory syndrome virus (PRRSV)-persistent infection. However, the mechanisms of PRRSV-ADE infection are still confusing. A clear understanding of the event upon virus infection by the ADE pathway has become crucial for developing efficient intervention of the PRRSV infection. In this study, an ADE assay showed that PRRSV-ADE infection in porcine alveolar macrophages (AMs) significantly decreased the production of interferon-α (IFN-α) and tumor necrosis factor-α (TNF-α), and significantly increased the production of interleukine-10 (IL-10). A gene knockdown assay based on small interfering RNA (siRNA) showed that both Fc gamma receptor I (FcγRI) and FcγRIII in porcine AMs were involved in PRRSV-ADE infection. An activation assay showed that specific activation of FcγRI or FcγRIII in porcine AMs during PRRSV infection not only significantly decreased the production of IFN-α and TNF-α, but also significantly increased the production of IL-10 and significantly facilitated PRRSV replication. In conclusion, our studies suggested that ADE downregulated the production of IFN-α and TNF-α in porcine AMs maybe via FcγRI and FcγRIII, thereby leading to enhanced PRRSV infection. View Full-Text
Keywords: FcγRI; FcγRIII; PRRSV; ADE; IFN-α; TNF-α FcγRI; FcγRIII; PRRSV; ADE; IFN-α; TNF-α
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MDPI and ACS Style

Zhang, L.; Li, W.; Sun, Y.; Kong, L.; Xu, P.; Xia, P.; Zhang, G. Antibody-Mediated Porcine Reproductive and Respiratory Syndrome Virus Infection Downregulates the Production of Interferon-α and Tumor Necrosis Factor-α in Porcine Alveolar Macrophages via Fc Gamma Receptor I and III. Viruses 2020, 12, 187. https://doi.org/10.3390/v12020187

AMA Style

Zhang L, Li W, Sun Y, Kong L, Xu P, Xia P, Zhang G. Antibody-Mediated Porcine Reproductive and Respiratory Syndrome Virus Infection Downregulates the Production of Interferon-α and Tumor Necrosis Factor-α in Porcine Alveolar Macrophages via Fc Gamma Receptor I and III. Viruses. 2020; 12(2):187. https://doi.org/10.3390/v12020187

Chicago/Turabian Style

Zhang, Liujun, Wen Li, Yangyang Sun, Linghao Kong, Pengli Xu, Pingan Xia, and Gaiping Zhang. 2020. "Antibody-Mediated Porcine Reproductive and Respiratory Syndrome Virus Infection Downregulates the Production of Interferon-α and Tumor Necrosis Factor-α in Porcine Alveolar Macrophages via Fc Gamma Receptor I and III" Viruses 12, no. 2: 187. https://doi.org/10.3390/v12020187

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