Next Article in Journal
The Detection and Association of Canine Papillomavirus with Benign and Malignant Skin Lesions in Dogs
Previous Article in Journal
The First Non-LRV RNA Virus in Leishmania
Open AccessArticle

Pathogenetic Potential Relating to Metabolic Activity in a Mouse Model of Infection with the Chikungunya Virus East/Central/South African Genotype

1
Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan
2
Leading Graduate School Program, Nagasaki University, Nagasaki 852-8523, Japan
3
Laboratory of Veterinary Microbiology, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi 753-8515, Japan
*
Author to whom correspondence should be addressed.
Viruses 2020, 12(2), 169; https://doi.org/10.3390/v12020169
Received: 1 December 2019 / Revised: 17 January 2020 / Accepted: 30 January 2020 / Published: 3 February 2020
Epidemics of the Chikungunya virus (CHIKV) from 2004 onwards were caused by the East/Central/South African (ECSA) genotype. However, the pathogenesis of the genotype infection has not been fully explained. In this study, we examined the pathogenic potential of CHIKV ECSA genotype M-30 (M-30) by comparing it with that of African genotype S-27 (S-27) in mice. Following low titer infections in type-I IFN receptor KO (A129) mice, we found that the M-30 infection caused high and acute fatality compared with the S-27 infection. M-30-infected A129 mice showed higher viral loads in their central nervous systems and peripheral organs, and increased levels of IFN-γ responses in their brains. Interestingly, M-30-infected mice did not show the hypophagia and reductions in weight which were observed in S-27-infected mice. Our observations provide a novel explanation of the pathogenic mechanisms attributed to virus proliferation, anti-type-II IFN response and metabolic activity in the CHIKV ECSA virus in mice. View Full-Text
Keywords: CHIKV; ECSA; IFN-γ; mouse model; viral pathogenesis CHIKV; ECSA; IFN-γ; mouse model; viral pathogenesis
Show Figures

Figure 1

MDPI and ACS Style

Ngwe Tun, M.M.; Muthugala, R.; Kyaw Kyaw, A.; Shimada, S.; Morita, K.; Hayasaka, D. Pathogenetic Potential Relating to Metabolic Activity in a Mouse Model of Infection with the Chikungunya Virus East/Central/South African Genotype. Viruses 2020, 12, 169.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop