miRNAs as Potential Biomarkers for Viral Hepatitis B and C
Abstract
:1. Introduction
2. Fibrosis Progression
3. HBV Infection
4. HCV Infection
5. Micro-RNA: A Small Non-Coding RNA
6. miRNAs in Normal Liver Tissue
7. Hepatitis B Genome Encodes for Two Viral miRNAs: HBV-miR-2 and 3
7.1. HBV-miR-2
7.2. HBV-miR-3
8. HCV Replication Is Modulated by miR-122 Expression
9. miRNAs and the Immune System during Viral Hepatitis
10. miRNAs Expression during CHB and CHC Related Fibrosis
10.1. Dysregulation of Anti-Fibrogenic miRNAs in CHB
10.1.1. miR-29
10.1.2. miR-122
10.1.3. miR-143
10.1.4. miR-185
10.2. Dysregulation of Pro-Fibrogenic miRNAs in CHB
10.2.1. miR-21
10.2.2. miR-221 and miR-222
10.2.3. miR-223
10.3. Dysregulations of Anti-Fibrogenic miRNAs in CHC
10.3.1. miR-29
10.3.2. miR-122
10.3.3. miR-143
10.3.4. miR-185
10.4. Dysregulations of Pro-Fibrogenic miRNAs in CHC
10.4.1. miR-21
10.4.2. miR-221 and miR-222
10.4.3. miR-223
11. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Chronic Hepatitis B | Chronic Hepatitis C | Refs | |||||||
---|---|---|---|---|---|---|---|---|---|
miRNAs | Chr | F0-F1-F2 | F3-F4 | HCC | F0-F1-F2 | F3-F4 | HCC | ||
Anti-Fibrogenic | miR-29 | 7q32.3; 1q32.2 | ↓ | ↓ | ↓ | = | = | = | [54,55,56,57,58,59] |
miR-122 | 18 | ↑ | ↑ | ↓ | ↓ | ↓ | ↓ | [14,60,61,62,63,64,65] | |
miR-143 | 5q32 | ↓ | ↓ | ↓ | ↑ | ↑ | nd | [55,66,67,68,69] | |
miR-185 | 22q11.2 | ↑ | ↑ | ↑ | nd | nd | ↓ | [70,71,72] | |
Pro-Fibrogenic | miR-21 | 17q23.1 | ↓ | ↓ | = | = | = | = | [55,73,74,75,76] |
miR-221 | X | = | = | = | = | = | = | [14,77] | |
miR-222 | X | = | = | = | = | = | = | ||
miR-223 | Xq12 | ↓ | ↓ | ↓ | ↑ | ↑ | ↓ | [55,78,79,80,81] |
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Loureiro, D.; Tout, I.; Narguet, S.; Benazzouz, S.M.; Mansouri, A.; Asselah, T. miRNAs as Potential Biomarkers for Viral Hepatitis B and C. Viruses 2020, 12, 1440. https://doi.org/10.3390/v12121440
Loureiro D, Tout I, Narguet S, Benazzouz SM, Mansouri A, Asselah T. miRNAs as Potential Biomarkers for Viral Hepatitis B and C. Viruses. 2020; 12(12):1440. https://doi.org/10.3390/v12121440
Chicago/Turabian StyleLoureiro, Dimitri, Issam Tout, Stéphanie Narguet, Sabrina Menasria Benazzouz, Abdellah Mansouri, and Tarik Asselah. 2020. "miRNAs as Potential Biomarkers for Viral Hepatitis B and C" Viruses 12, no. 12: 1440. https://doi.org/10.3390/v12121440