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Editorial

Special Issue: Bovine Viral Diarrhea Virus and Related Pestiviruses

by
Helle Bielefeldt-Ohmann
1,2,3
1
Australian Infectious Diseases Research Centre, The University of Queensland, St. Lucia, QLD 4072, Australia
2
School of Veterinary Science, The University of Queensland, Gatton Campus, QLD 4343, Australia
3
School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, QLD 4072, Australia
Viruses 2020, 12(10), 1181; https://doi.org/10.3390/v12101181
Submission received: 13 October 2020 / Accepted: 16 October 2020 / Published: 19 October 2020
(This article belongs to the Special Issue Bovine Viral Diarrhea Virus and Related Pestiviruses)
The genus Pestivirus, encompassing small positive-strand RNA viruses in the family Flaviviridae, comprises four viruses of very significant economic impact to the cattle, swine and sheep industries worldwide: bovine viral diarrhoea virus (BVDV) type 1 and type 2, classical swine fever virus (CSFV) and border disease virus (BDV). Both BVDV- and CSFV-related disease syndromes have been recognised for over 70 years and major progress has been made in elucidating the pathogenesis of these important infections of ruminants and pigs. While much research effort rightfully has gone into epidemiology, diagnostics and prevention—and continues to do so—BVDV and CSFV have also served as excellent models for understanding mechanisms in RNA-virus biology [1,2], transplacental virus infection [3], and host responses to persistent virus infection [4,5]. More recently, a number of novel viruses have been detected in wild and domestic animals by isolation and/or virome studies, and which appear to be related to the pestiviruses and qualify as new pestivirus species. Much still remains to be learned about these latter viruses, including host spectrum, virus–host interactions, epidemiology and clinical spectrum.
This Special Issue of Viruses encompasses a range of reports on various aspects of pestiviruses, including an overview of the bovine pestiviruses with an update on the current—albeit still not widely used—nomenclature of the pestiviruses [6]. The epidemiology of pestiviruses remains a subject of considerable interest, as it impinges on biosecurity, susceptibility to secondary infections, management strategies, including vaccination versus eradication, and the importance of potential wildlife reservoirs [7,8,9,10,11].
A first and fundamental step in a viral infection, is attachment to a cellular membrane molecule, a viral receptor. In this issue, two articles focus on the purported receptor for BVDV, bovine CD46 [12,13], describing new tools for the study of the interaction between BVDV and CD46 and suggesting, perhaps not surprisingly considering what we know about receptors for other viruses [14], that CD46 may be but one of two or more molecules on the target cell surface membrane necessary for viral uptake [12].
The interaction of pestiviruses with the host immune system has been a focus of research for decades, notably for BVDV. In this issue the effect of congenital (transplacental) BVDV infection and persistence on the development of innate and adaptive immune functions is explored in an experimental infection model [15]. Monocytes and macrophages are known target cells in both acute-transient [16] and persistent [17,18] BVDV infections. Given the central role of these cells in both the innate and adaptive immune responses, one might expect profound and potentially adverse effects, and this is explored in one article in this issue [19].
One of the characteristics of the pestiviruses, at least the ruminant pestiviruses, is the lack of strict species specificity [6,20]. This can present challenges with regard to serology-based diagnostics, biosecurity and eradication programmes [6,20]. It may also disguise the appearance and diagnosis of new and emerging pestivirus infections, and it is therefore paramount that we gain a better understanding of these new entities and refine diagnostic capabilities—both at the clinical and the virological level. In this issue, several articles focus on three of these new pestiviruses and the diseases they may cause in pigs and ruminants: LINDA virus [21], atypical porcine pestivirus (APPV or Pestivirus K), which by now has been detected in many parts of the world [22,23,24,25], and Bungowannah virus (Pestivirus F) [26,27,28].
It is the hope that this issue, which has brought together contributions from multiple disciplines—virology, immunology, veterinary clinical medicine, epidemiology and pathology—will stimulate further exploration of this fascinating group of viruses in the future. There remains many questions to be addressed even in those very same areas dealt with in this issue, including the conditions, at both the cellular and organismic level, that are conducive to events leading to biotype-switch, viral persistence, emergence of new pestivirus diseases as well as some of the discrepancies between in vitro and in vivo results in regard to immune responses—to mention just a few. Development of new approaches to the investigation of “old” and new pestiviruses are already under way [12,13,29] and others are likely to become available in the future.

Funding

This research received no external funding.

Conflicts of Interest

The authors declares no conflict of interest.

References

  1. Tautz, N.; Tews, B.A.; Meyers, G. The molecular biology of pestiviruses. Adv. Virus Res. 2015, 93, 47–160. [Google Scholar] [CrossRef] [PubMed]
  2. Becher, P.; Tautz, N. RNA recombination in pestiviruses: Cellular RNA sequences in viral genomes highlight the role of host factors for viral persistence and lethal disease. RNA Biol. 2011, 8, 216–224. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  3. Hansen, T.R.; Smirnova, N.P.; Webb, B.T.; Bielefeldt-Ohmann, H.; Sacco, R.E.; Van Campen, H. Innate and adaptive immune responses to in utero infection with bovine viral diarrhea virus. Anim. Health Res. Rev. 2015, 16, 15–26. [Google Scholar] [CrossRef]
  4. Schweizer, M.; Peterhans, E. Pestiviruses. Annu. Rev. Anim. Biosci. 2014, 2, 141–163. [Google Scholar] [CrossRef]
  5. Georges, H.M.; Knapek, K.J.; Bielefeldt-Ohmann, H.; Van Campen, H.; Hansen, T.R. Attenuated lymphocyte activation leads to the development of immunetolerance in bovine fetuses persistently infected with bovine viral diarrhea virus. Biol. Reprod. 2020, 103, 560–571. [Google Scholar] [CrossRef] [PubMed]
  6. Riitho, V.; Strong, R.; Larska, M.; Graham, S.; Steinbach, F. Bovine pestivirus heterogeneity and its potential impact on vaccination and diagnosis. Viruses 2020, 12, 1134. [Google Scholar] [CrossRef] [PubMed]
  7. Basqueira, N.; Ramos, J.; Torres, F.; Okuda, L.; Hurley, D.; Chase, C.; Gomes, A.; Gomes, V. An assessment of secondary clinical disease, milk production and quality, and the impact on reproduction in Holstein heifers and cows from a single large commercial herd persistently infected with bovine viral diarrhea virus type 2. Viruses 2020, 12, 760. [Google Scholar] [CrossRef]
  8. McGowan, M.; McCosker, K.; Fordyce, G.; Kirkland, P. Epidemiology and management of BVDV in rangeland beef breeding herds in Northern Australia. Viruses 2020, 12, 1063. [Google Scholar] [CrossRef]
  9. das Neves, C.; Johansson Wensman, J.; Nymo, I.; Skjerve, E.; Alenius, S.; Tryland, M. Pestivirus infections in semi-domesticated Eurasian tundra reindeer (Rangifer tarandus tarandus): A retrospective cross-sectional serological study in Finnmark County, Norway. Viruses 2020, 12, 29. [Google Scholar] [CrossRef] [Green Version]
  10. Huaman, J.; Pacioni, C.; Forsyth, D.; Pople, A.; Hampton, J.; Carvalho, T.; Helbig, K. Serosurveillance and molecular investigation of wild deer in Australia reveals seroprevalence of Pestivirus infection. Viruses 2020, 12, 752. [Google Scholar] [CrossRef]
  11. Read, A.; Gestier, S.; Parrish, K.; Finlaison, D.; Gu, X.; O’Connor, T.; Kirkland, P. Prolonged detection of bovine viral diarrhoea virus infection in the semen of bulls. Viruses 2020, 12, 674. [Google Scholar] [CrossRef]
  12. Riedel, C.; Chen, H.; Reichart, U.; Lamp, B.; Laketa, V.; Rümenapf, T. Real time analysis of bovine viral diarrhea virus (BVDV) infection and its dependence on bovine CD46. Viruses 2020, 12, 116. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  13. Szillat, K.; Koethe, S.; Wernike, K.; Höper, D.; Beer, M. A CRISPR/Cas9 generated bovine CD46-knockout cell line—A tool to elucidate the adaptability of bovine viral diarrhea viruses (BVDV). Viruses 2020, 12, 859. [Google Scholar] [CrossRef] [PubMed]
  14. Maginnis, M.S. Virus-Receptor Interactions: The key to cellular invasion. J. Mol. Biol. 2018, 430, 2590–2611. [Google Scholar] [CrossRef]
  15. Knapek, K.; Georges, H.; Van Campen, H.; Bishop, J.; Bielefeldt-Ohmann, H.; Smirnova, N.; Hansen, T. Fetal lymphoid organ immune responses to transient and persistent infection with bovine viral diarrhea virus. Viruses 2020, 12, 816. [Google Scholar] [CrossRef]
  16. Liebler-Tenorio, E.M.; Ridpath, J.F.; Neill, J.D. Distribution of viral antigen and development of lesions after experimental infection of calves with a BVDV 2 strain of low virulence. J. Vet. Diagn. Investig. 2003, 15, 221–232. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  17. Bielefeldt-Ohmann, H.; Ronsholt, L.; Bloch, B. Demonstration of bovine viral diarrhoea virus in peripheral blood mononuclear cells of persistently infected, clinically normal cattle. J. Gen. Virol. 1987, 68, 1971–1982. [Google Scholar] [CrossRef]
  18. Bielefeldt-Ohmann, H. In situ characterization of mononuclear leukocytes in skin and digestive tract of persistently bovine viral diarrhea virus-infected clinically healthy calves and calves with mucosal disease. Vet. Pathol. 1988, 25, 304–309. [Google Scholar] [CrossRef] [Green Version]
  19. Abdelsalam, K.; Rajput, M.; Elmowalid, G.; Sobraske, J.; Thakur, N.; Abdallah, H.; Ali, A.; Chase, C.C.L. The effect of bovine viral diarrhea virus (BVDV) strains and the corresponding infected-macrophages’ supernatant on macrophage inflammatory function and lymphocyte apoptosis. Viruses 2020, 12, 701. [Google Scholar] [CrossRef]
  20. de Oliveira, L.; Mechler-Dreibi, M.; Almeida, H.; Gatto, I. Bovine viral diarrhea virus: Recent findings about its occurrence in pigs. Viruses 2020, 12, 600. [Google Scholar] [CrossRef]
  21. Kiesler, A.; Seitz, K.; Schwarz, L.; Buczolich, K.; Petznek, H.; Sassu, E.; Dürlinger, S.; Högler, S.; Klang, A.; Riedel, C.; et al. Clinical and serological evaluation of LINDA virus infections in post-weaning piglets. Viruses 2019, 11, 975. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  22. Dall Agnol, A.; Alfieri, A.; Alfieri, A. Pestivirus K (atypical porcine pestivirus): Update on the virus, viral infection, and the association with congenital tremor in newborn piglets. Viruses 2020, 12, 903. [Google Scholar] [CrossRef] [PubMed]
  23. Sozzi, E.; Salogni, C.; Lelli, D.; Barbieri, I.; Moreno, A.; Alborali, G.; Lavazza, A. Molecular survey and phylogenetic analysis of atypical porcine pestivirus (APPV) identified in swine and wild boar from Northern Italy. Viruses 2019, 11, 1142. [Google Scholar] [CrossRef] [Green Version]
  24. Choe, S.; Park, G.; Cha, R.; Hyun, B.; Park, B.; An, D. Prevalence and genetic diversity of atypical porcine pestivirus (APPV) detected in South Korean wild boars. Viruses 2020, 12, 680. [Google Scholar] [CrossRef] [PubMed]
  25. Folgueiras-González, A.; van den Braak, R.; Simmelink, B.; Deijs, M.; van der Hoek, L.; de Groof, A. Atypical porcine pestivirus circulation and molecular evolution within an affected swine herd. Viruses 2020, 12, 1080. [Google Scholar] [CrossRef]
  26. Finlaison, D.; Kirkland, P. The outcome of porcine foetal infection with Bungowannah virus is dependent on the stage of gestation at which infection occurs. Part 1: Serology and virology. Viruses 2020, 12, 691. [Google Scholar] [CrossRef]
  27. Finlaison, D.; Kirkland, P. The outcome of porcine foetal infection with Bungowannah virus is dependent on the stage of gestation at which infection occurs. Part 2: Clinical signs and gross pathology. Viruses 2020, 12, 873. [Google Scholar] [CrossRef]
  28. Read, A.; Finlaison, D.; Kirkland, P. Infection of ruminants, including pregnant cattle, with Bungowannah virus. Viruses 2020, 12, 690. [Google Scholar] [CrossRef]
  29. Dalmann, A.; Wernike, K.; Snijder, E.; Oreshkova, N.; Reimann, I.; Beer, M. Single-round infectious particle production by DNA-launched infectious clones of Bungowannah virus. Viruses 2020, 12, 847. [Google Scholar] [CrossRef]
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Bielefeldt-Ohmann, H. Special Issue: Bovine Viral Diarrhea Virus and Related Pestiviruses. Viruses 2020, 12, 1181. https://doi.org/10.3390/v12101181

AMA Style

Bielefeldt-Ohmann H. Special Issue: Bovine Viral Diarrhea Virus and Related Pestiviruses. Viruses. 2020; 12(10):1181. https://doi.org/10.3390/v12101181

Chicago/Turabian Style

Bielefeldt-Ohmann, Helle. 2020. "Special Issue: Bovine Viral Diarrhea Virus and Related Pestiviruses" Viruses 12, no. 10: 1181. https://doi.org/10.3390/v12101181

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Bielefeldt-Ohmann, H. (2020). Special Issue: Bovine Viral Diarrhea Virus and Related Pestiviruses. Viruses, 12(10), 1181. https://doi.org/10.3390/v12101181

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