Next Article in Journal
Mis-Genotyping of Some Hepatitis D Virus Genotype 2 and 5 Sequences Using HDVdb
Next Article in Special Issue
Lassa Virus Vaccine Candidate ML29 Generates Truncated Viral RNAs Which Contribute to Interfering Activity and Attenuation
Previous Article in Journal
Multisubunit RNA Polymerases of Jumbo Bacteriophages
Previous Article in Special Issue
Effect of Strain Variations on Lassa Virus Z Protein-Mediated Human RIG-I Inhibition

A Sporadic and Lethal Lassa Fever Case in Forest Guinea, 2019

Laboratoire des Fièvres Hémorragiques en Guinée, Conakry, Guinea
Agence Nationale de Sécurité Sanitaire, Ministry of Health, Conakry, Guinea
Virology Department, Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany
Virology Department, German Center for Infection Research (DZIF), partner site Hamburg–Lübeck–Borstel–Riems, 20359 Hamburg, Germany
Author to whom correspondence should be addressed.
Viruses 2020, 12(10), 1062;
Received: 24 August 2020 / Revised: 18 September 2020 / Accepted: 21 September 2020 / Published: 23 September 2020
(This article belongs to the Special Issue Arenaviruses 2020)
Lassa fever is a rodent-borne disease caused by Lassa virus (LASV). It causes fever, dizziness, vertigo, fatigue, coughing, diarrhea, internal bleeding and facial edema. The disease has been known in Guinea since 1960 but only anectodical acute cases have been reported to date. In January 2019, a 35-year-old man, a wood merchant from Kissidougou, Forest Guinea, presented himself at several health centers with persistent fever, frequent vomiting and joint pain. He was repeatedly treated for severe malaria, and died three weeks later in Mamou regional hospital. Differential diagnosis identified LASV as the cause of death. No secondary cases were reported. The complete LASV genome was obtained using next-generation sequencing. Phylogenetic analysis showed that this strain, namely the Kissidougou strain, belongs to the clade IV circulating in Guinea and Sierra Leone, and is thought to have emerged some 150 years ago. Due to the similarity of symptoms with malaria, Lassa fever is still a disease that is difficult to recognize and that may remain undiagnosed in health centers in Guinea. View Full-Text
Keywords: Lassa fever; Kissidougou; Guinea; Lassa genome; phylogeny Lassa fever; Kissidougou; Guinea; Lassa genome; phylogeny
Show Figures

Figure 1

MDPI and ACS Style

Magassouba, N.; Koivogui, E.; Conde, S.; Kone, M.; Koropogui, M.; Soropogui, B.; Kekoura, I.; Hinzmann, J.; Günther, S.; Keita, S.; Duraffour, S.; Fichet-Calvet, E. A Sporadic and Lethal Lassa Fever Case in Forest Guinea, 2019. Viruses 2020, 12, 1062.

AMA Style

Magassouba N, Koivogui E, Conde S, Kone M, Koropogui M, Soropogui B, Kekoura I, Hinzmann J, Günther S, Keita S, Duraffour S, Fichet-Calvet E. A Sporadic and Lethal Lassa Fever Case in Forest Guinea, 2019. Viruses. 2020; 12(10):1062.

Chicago/Turabian Style

Magassouba, N’Faly, Enogo Koivogui, Sory Conde, Moussa Kone, Michel Koropogui, Barrè Soropogui, Ifono Kekoura, Julia Hinzmann, Stephan Günther, Sakoba Keita, Sophie Duraffour, and Elisabeth Fichet-Calvet. 2020. "A Sporadic and Lethal Lassa Fever Case in Forest Guinea, 2019" Viruses 12, no. 10: 1062.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop