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Article

A Sporadic and Lethal Lassa Fever Case in Forest Guinea, 2019

1
Laboratoire des Fièvres Hémorragiques en Guinée, Conakry, Guinea
2
Agence Nationale de Sécurité Sanitaire, Ministry of Health, Conakry, Guinea
3
Virology Department, Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany
4
Virology Department, German Center for Infection Research (DZIF), partner site Hamburg–Lübeck–Borstel–Riems, 20359 Hamburg, Germany
*
Author to whom correspondence should be addressed.
Viruses 2020, 12(10), 1062; https://doi.org/10.3390/v12101062
Received: 24 August 2020 / Revised: 18 September 2020 / Accepted: 21 September 2020 / Published: 23 September 2020
(This article belongs to the Special Issue Arenaviruses 2020)
Lassa fever is a rodent-borne disease caused by Lassa virus (LASV). It causes fever, dizziness, vertigo, fatigue, coughing, diarrhea, internal bleeding and facial edema. The disease has been known in Guinea since 1960 but only anectodical acute cases have been reported to date. In January 2019, a 35-year-old man, a wood merchant from Kissidougou, Forest Guinea, presented himself at several health centers with persistent fever, frequent vomiting and joint pain. He was repeatedly treated for severe malaria, and died three weeks later in Mamou regional hospital. Differential diagnosis identified LASV as the cause of death. No secondary cases were reported. The complete LASV genome was obtained using next-generation sequencing. Phylogenetic analysis showed that this strain, namely the Kissidougou strain, belongs to the clade IV circulating in Guinea and Sierra Leone, and is thought to have emerged some 150 years ago. Due to the similarity of symptoms with malaria, Lassa fever is still a disease that is difficult to recognize and that may remain undiagnosed in health centers in Guinea. View Full-Text
Keywords: Lassa fever; Kissidougou; Guinea; Lassa genome; phylogeny Lassa fever; Kissidougou; Guinea; Lassa genome; phylogeny
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MDPI and ACS Style

Magassouba, N.; Koivogui, E.; Conde, S.; Kone, M.; Koropogui, M.; Soropogui, B.; Kekoura, I.; Hinzmann, J.; Günther, S.; Keita, S.; Duraffour, S.; Fichet-Calvet, E. A Sporadic and Lethal Lassa Fever Case in Forest Guinea, 2019. Viruses 2020, 12, 1062. https://doi.org/10.3390/v12101062

AMA Style

Magassouba N, Koivogui E, Conde S, Kone M, Koropogui M, Soropogui B, Kekoura I, Hinzmann J, Günther S, Keita S, Duraffour S, Fichet-Calvet E. A Sporadic and Lethal Lassa Fever Case in Forest Guinea, 2019. Viruses. 2020; 12(10):1062. https://doi.org/10.3390/v12101062

Chicago/Turabian Style

Magassouba, N’Faly, Enogo Koivogui, Sory Conde, Moussa Kone, Michel Koropogui, Barrè Soropogui, Ifono Kekoura, Julia Hinzmann, Stephan Günther, Sakoba Keita, Sophie Duraffour, and Elisabeth Fichet-Calvet. 2020. "A Sporadic and Lethal Lassa Fever Case in Forest Guinea, 2019" Viruses 12, no. 10: 1062. https://doi.org/10.3390/v12101062

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