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Chronic Hepatitis B Virus Infection Associated with Increased Colorectal Cancer Risk in Taiwanese Population

by Fu-Hsiung Su 1,2,3, Thi Nga Le 4, Chih-Hsin Muo 5, Sister Arlene Te 1,2, Fung-Chang Sung 5,6,*,† and Chih-Ching Yeh 3,7,8,*,†
1
Department of Family Medicine, Cardinal Tien Hospital, Fu Jen Catholic University, New Taipei City 231, Taiwan
2
School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City 242, Taiwan
3
School of Public Health, College of Public Health, Taipei Medical University, Taipei 110, Taiwan
4
International Master/PhD Program, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
5
Management Office for Health Data, China Medical University Hospital, Taichung 404, Taiwan
6
Department of Health Services Administration, College of Public Health, China Medical University, Taichung 404, Taiwan
7
Department of Public Health, College of Public Health, China Medical University, Taichung 404, Taiwan
8
Cancer Center, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Viruses 2020, 12(1), 97; https://doi.org/10.3390/v12010097
Received: 13 December 2019 / Revised: 7 January 2020 / Accepted: 10 January 2020 / Published: 14 January 2020
(This article belongs to the Section Animal Viruses)
Chronic hepatitis B virus (HBV) infections and colorectal cancer (CRC) are prevalent in Taiwan. We carried out a population-based case-control study to assess the association between HBV infection and CRC risk. Using the National Health Insurance Research Database of Taiwan, we identified 69,478 newly diagnosed patients with CRC from 2005 to 2011. We further randomly selected 69,478 age- and gender-matched controls without CRC from the same database. Odds ratios (ORs) were calculated to evaluate the association between chronic HBV infection and CRC using a logistic regression analysis. HBV infection was found to be associated with the risk of CRC (OR = 1.27, 95% confidence interval (CI) = 1.20–1.33). This relationship was similar in men and women. Age-specific analysis revealed that the CRC risk associated with HBV decreased with age. The adjusted ORs for patients aged <55, 55–64, and 65–74 years were 1.63 (95% CI = 1.48–1.79), 1.24 (95% CI = 1.13–1.37), and 1.02 (95% = 0.92–1.13), respectively. In conclusion, this study suggests that chronic HBV infection is significantly associated with an increased risk of CRC. Monitoring the risk of CRC development in young patients with HBV infection is crucial. View Full-Text
Keywords: colorectal cancer; hepatitis B virus; population-based; case-control study colorectal cancer; hepatitis B virus; population-based; case-control study
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Su, F.-H.; Le, T.N.; Muo, C.-H.; Te, S.A.; Sung, F.-C.; Yeh, C.-C. Chronic Hepatitis B Virus Infection Associated with Increased Colorectal Cancer Risk in Taiwanese Population. Viruses 2020, 12, 97.

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