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Pulmonary Involvement during the Ebola Virus Disease

1
National Institute for Infectious Diseases ‘Lazzaro Spallanzani’ IRCCS, 00149 Rome, Italy
2
International Public Health Crisis Group, 00149 Rome, Italy
3
EMERGENCY Onlus NGO, Via Santa Croce 19, 20122 Milan, Italy
4
International Public Health Crisis Group, London WC1E 6BT, UK
5
Division of Infection and Immunity, National Institute for Health Research Biomedical Research Centre at University College London Hospitals NHS Foundation Trust, London WC1E 6BT, UK
6
International Public Health Crisis Group, Quebec City, PQ G1V 0A6, Canada
7
Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB R3E 0J9, Canada
8
Département de microbiologie-infectiologie et d’immunologie, Université Laval, Québec, PQ G1V 0A6, Canada
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Viruses 2019, 11(9), 780; https://doi.org/10.3390/v11090780
Received: 29 July 2019 / Revised: 20 August 2019 / Accepted: 22 August 2019 / Published: 24 August 2019
(This article belongs to the Special Issue Medical Advances in Viral Hemorrhagic Fever Research)
Filoviruses have become a worldwide public health concern, especially during the 2013–2016 Western Africa Ebola virus disease (EVD) outbreak—the largest outbreak, both by number of cases and geographical extension, recorded so far in medical history. EVD is associated with pathologies in several organs, including the liver, kidney, and lung. During the 2013–2016 Western Africa outbreak, Ebola virus (EBOV) was detected in the lung of infected patients suggesting a role in lung pathogenesis. However, little is known about lung pathogenesis and the controversial issue of aerosol transmission in EVD. This review highlights the pulmonary involvement in EVD, with a special focus on the new data emerging from the 2013–2016 Ebola outbreak. View Full-Text
Keywords: Ebola virus; lung pathogenesis; respiratory disease; Ebola virus disease Ebola virus; lung pathogenesis; respiratory disease; Ebola virus disease
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Lalle, E.; Biava, M.; Nicastri, E.; Colavita, F.; Di Caro, A.; Vairo, F.; Lanini, S.; Castilletti, C.; Langer, M.; Zumla, A.; Kobinger, G.; Capobianchi, M.R.; Ippolito, G. Pulmonary Involvement during the Ebola Virus Disease. Viruses 2019, 11, 780.

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