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Clinical Evaluation of QuickNaviTM-Ebola in the 2018 Outbreak of Ebola Virus Disease in the Democratic Republic of the Congo

1
Institut National de Recherche Biomédicale, Avenue de la Démocratie, Kinshasa/Gombe-P.O. Box 1197, Kinshasa I, Democratic Republic of the Congo
2
Service de Microbiologie, Cliniques Universitaires de Kinshasa, Kinshasa, Democratic Republic of the Congo
3
Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium
4
Outbreak Research team, Institute of Tropical Medicine, Antwerp, Belgium
5
Denka Seiken Co., Ltd., 1359-1, Kagamida, Kigoshi, Gosen, Niigata 959-1695, Japan
6
Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Kita-20, Nishi-10, Kita-ku, Sapporo 001-0020, Japan
7
School of Veterinary Medicine, the University of Zambia, Great East Road Campus, Lusaka, Zambia
8
Africa Center of Excellence for Infectious Diseases of Humans and Animals, the University of Zambia, Lusaka, Zambia
9
Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education, Hokkaido University, Kita-20, Nishi-10, Kita-ku, Sapporo 001-0020, Japan
*
Author to whom correspondence should be addressed.
Viruses 2019, 11(7), 589; https://doi.org/10.3390/v11070589
Received: 20 May 2019 / Revised: 20 June 2019 / Accepted: 26 June 2019 / Published: 28 June 2019
(This article belongs to the Special Issue Medical Advances in Viral Hemorrhagic Fever Research)
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Abstract

The recent large outbreaks of Ebola virus disease (EVD) in West Africa and the Democratic Republic of the Congo (DRC) have highlighted the need for rapid diagnostic tests to control this disease. In this study, we clinically evaluated a previously developed immunochromatography-based kit, QuickNaviTM-Ebola. During the 2018 outbreaks in DRC, 928 blood samples from EVD-suspected cases were tested with QuickNaviTM-Ebola and the WHO-approved GeneXpert. The sensitivity and specificity of QuickNaviTM-Ebola, estimated by comparing it to GeneXpert-confirmed cases, were 85% (68/80) and 99.8% (846/848), respectively. These results indicate the practical reliability of QuickNaviTM-Ebola for point-of-care diagnosis of EVD. View Full-Text
Keywords: Ebola virus; EVD; rapid diagnostic test; immunochromatography; QuickNavi; DRC Ebola virus; EVD; rapid diagnostic test; immunochromatography; QuickNavi; DRC
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Makiala, S.; Mukadi, D.; De Weggheleire, A.; Muramatsu, S.; Kato, D.; Inano, K.; Gondaira, F.; Kajihara, M.; Yoshida, R.; Changula, K.; Mweene, A.; Mbala-Kingebeni, P.; Muyembe-Tamfum, J.-J.; Masumu, J.; Ahuka, S.; Takada, A. Clinical Evaluation of QuickNaviTM-Ebola in the 2018 Outbreak of Ebola Virus Disease in the Democratic Republic of the Congo. Viruses 2019, 11, 589.

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