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Norovirus Attachment and Entry

Departments of Laboratory Medicine and Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
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Viruses 2019, 11(6), 495; https://doi.org/10.3390/v11060495
Received: 30 April 2019 / Revised: 24 May 2019 / Accepted: 25 May 2019 / Published: 30 May 2019
(This article belongs to the Special Issue Noroviruses)
Human norovirus is a major human pathogen causing the majority of cases of viral gastroenteritis globally. Viral entry is the first step of the viral life cycle and is a significant determinant of cell tropism, host range, immune interactions, and pathogenesis. Bile salts and histo-blood group antigens are key mediators of norovirus entry; however, the molecular mechanisms by which these molecules promote infection and the identity of a potential human norovirus receptor remain unknown. Recently, there have been several important advances in norovirus entry biology including the identification of CD300lf as the receptor for murine norovirus and of the role of the minor capsid protein VP2 in viral genome release. Here, we will review the current understanding about norovirus attachment and entry and highlight important future directions. View Full-Text
Keywords: norovirus entry; CD300lf; JAM-A; bile salts; histo-blood group antigens; murine norovirus; viral tropism norovirus entry; CD300lf; JAM-A; bile salts; histo-blood group antigens; murine norovirus; viral tropism
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Graziano, V.R.; Wei, J.; Wilen, C.B. Norovirus Attachment and Entry. Viruses 2019, 11, 495.

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