Molecular Epidemiology of HIV-1 Subtype G in the Russian Federation
AbstractAlthough HIV-1 subtype A has predominated in Russia since the end of the 20th century, other viral variants also circulate in this country. The dramatic outbreak of HIV-1 subtype G in 1988-1990 represents the origin of this variant spreading in Russia. However, full genome sequencing of the nosocomial viral variant and an analysis of the current circulating variants have not been conducted. We performed near full-length genome sequencing and phylogenetic and recombination analyses of 11 samples; the samples were determined to be subtype G based on an analysis of the pol region. Three samples were reliably obtained from patients infected during the nosocomial outbreak. The other 8 samples were obtained from patients who were diagnosed in 2010–2015. Phylogenetic analysis confirmed that a man from the Democratic Republic of the Congo was the origin of the outbreak. We also found that currently circulating viral variants that were genotyped as subtype G according to their pol region are in fact unique recombinant forms. These recombinant forms are similar to the BG-recombinants from Western Europe, particularly Spain and Portugal. The limitations of subtyping based on the pol region suggest that these viral variants are more widespread in Europe than is currently supposed. View Full-Text
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Murzakova, A.; Kireev, D.; Baryshev, P.; Lopatukhin, A.; Serova, E.; Shemshura, A.; Saukhat, S.; Kolpakov, D.; Matuzkova, A.; Suladze, A.; Nosik, M.; Eremin, V.; Shipulin, G.; Pokrovsky, V. Molecular Epidemiology of HIV-1 Subtype G in the Russian Federation. Viruses 2019, 11, 348.
Murzakova A, Kireev D, Baryshev P, Lopatukhin A, Serova E, Shemshura A, Saukhat S, Kolpakov D, Matuzkova A, Suladze A, Nosik M, Eremin V, Shipulin G, Pokrovsky V. Molecular Epidemiology of HIV-1 Subtype G in the Russian Federation. Viruses. 2019; 11(4):348.Chicago/Turabian Style
Murzakova, Anastasia; Kireev, Dmitry; Baryshev, Pavel; Lopatukhin, Alexey; Serova, Ekaterina; Shemshura, Andrey; Saukhat, Sergey; Kolpakov, Dmitry; Matuzkova, Anna; Suladze, Alexander; Nosik, Marina; Eremin, Vladimir; Shipulin, German; Pokrovsky, Vadim. 2019. "Molecular Epidemiology of HIV-1 Subtype G in the Russian Federation." Viruses 11, no. 4: 348.
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