A Novel Hepacivirus in Wild Rodents from South America
AbstractThe Hepacivirus genus comprises single-stranded positive-sense RNA viruses within the family Flaviviridae. Several hepaciviruses have been identified in different mammals, including multiple rodent species in Africa, Asia, Europe, and North America. To date, no rodent hepacivirus has been identified in the South American continent. Here, we describe an unknown hepacivirus discovered during a metagenomic screen in Akodon montensis, Calomys tener, Oligoryzomys nigripes, Necromys lasiurus, and Mus musculus from São Paulo State, Brazil. Molecular detection of this novel hepacivirus by RT-PCR showed a frequency of 11.11% (2/18) in Oligoryzomys nigripes. This is the first identification of hepavivirus in sigmondonine rodents and in rodents from South America. In sum, our results expand the host range, viral diversity, and geographical distribution of the Hepacivirus genus. View Full-Text
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Link: http://Table S1, Figure S1 and Figure S2
Description: Table S1: Percentages of contig assemblies of each pool. Figure S1: Alignment of primer sets region with representative hepacivirus sequences. Figure S2: Mapping of reads against genomes of Oligoryzomys hepacivirus.
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de Souza, W.M.; Fumagalli, M.J.; Sabino-Santos, G., Jr.; Motta Maia, F.G.; Modha, S.; Teixeira Nunes, M.R.; Murcia, P.R.; Moraes Figueiredo, L.T. A Novel Hepacivirus in Wild Rodents from South America. Viruses 2019, 11, 297.
de Souza WM, Fumagalli MJ, Sabino-Santos G, Jr, Motta Maia FG, Modha S, Teixeira Nunes MR, Murcia PR, Moraes Figueiredo LT. A Novel Hepacivirus in Wild Rodents from South America. Viruses. 2019; 11(3):297.Chicago/Turabian Style
de Souza, William M.; Fumagalli, Marcílio J.; Sabino-Santos, Gilberto, Jr.; Motta Maia, Felipe G.; Modha, Sejal; Teixeira Nunes, Márcio R.; Murcia, Pablo R.; Moraes Figueiredo, Luiz T. 2019. "A Novel Hepacivirus in Wild Rodents from South America." Viruses 11, no. 3: 297.
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