Next Article in Journal
Functional RNA Structures in the 3′UTR of Tick-Borne, Insect-Specific and No-Known-Vector Flaviviruses
Previous Article in Journal
A Field Recombinant Strain Derived from Two Type 1 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV-1) Modified Live Vaccines Shows Increased Viremia and Transmission in SPF Pigs
Article Menu
Issue 3 (March) cover image

Export Article

Open AccessCommunication
Viruses 2019, 11(3), 297; https://doi.org/10.3390/v11030297

A Novel Hepacivirus in Wild Rodents from South America

1
Virology Research Center, Ribeirão Preto Medical School, University of São Paulo,14049-900 Ribeirão Preto, São Paulo, Brazil
2
MRC-University of Glasgow Centre for Virus Research, Glasgow G61 1QH, UK
3
Department of Genetics, Evolution and Bioagents, Institute of Biology, University of Campinas, 13083-862 Campinas, São Paulo, Brazil
4
Institute of Biomedical Sciences, University of São Paulo, 05508-900 São Paulo, São Paulo, Brazil
5
Center for Technological Innovations, Evandro Chagas Institute, Ministry of Health, Ananindeua, 67030-000 Pará, Pará, Brazil
*
Author to whom correspondence should be addressed.
Received: 22 January 2019 / Revised: 11 March 2019 / Accepted: 18 March 2019 / Published: 24 March 2019
(This article belongs to the Section Animal Viruses)
  |  
PDF [1446 KB, uploaded 24 March 2019]
  |  

Abstract

The Hepacivirus genus comprises single-stranded positive-sense RNA viruses within the family Flaviviridae. Several hepaciviruses have been identified in different mammals, including multiple rodent species in Africa, Asia, Europe, and North America. To date, no rodent hepacivirus has been identified in the South American continent. Here, we describe an unknown hepacivirus discovered during a metagenomic screen in Akodon montensis, Calomys tener, Oligoryzomys nigripes, Necromys lasiurus, and Mus musculus from São Paulo State, Brazil. Molecular detection of this novel hepacivirus by RT-PCR showed a frequency of 11.11% (2/18) in Oligoryzomys nigripes. This is the first identification of hepavivirus in sigmondonine rodents and in rodents from South America. In sum, our results expand the host range, viral diversity, and geographical distribution of the Hepacivirus genus. View Full-Text
Keywords: Viral hepatitis; Hepacivirus; Flaviviridae Viral hepatitis; Hepacivirus; Flaviviridae
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary materials

  • Supplementary File 1:

    ZIP-Document (ZIP, 822 KB)

  • Externally hosted supplementary file 1
    Link: http://Table S1, Figure S1 and Figure S2
    Description: Table S1: Percentages of contig assemblies of each pool. Figure S1: Alignment of primer sets region with representative hepacivirus sequences. Figure S2: Mapping of reads against genomes of Oligoryzomys hepacivirus.
SciFeed

Share & Cite This Article

MDPI and ACS Style

de Souza, W.M.; Fumagalli, M.J.; Sabino-Santos, G., Jr.; Motta Maia, F.G.; Modha, S.; Teixeira Nunes, M.R.; Murcia, P.R.; Moraes Figueiredo, L.T. A Novel Hepacivirus in Wild Rodents from South America. Viruses 2019, 11, 297.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top