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A Novel Hepacivirus in Wild Rodents from South America

Virology Research Center, Ribeirão Preto Medical School, University of São Paulo,14049-900 Ribeirão Preto, São Paulo, Brazil
MRC-University of Glasgow Centre for Virus Research, Glasgow G61 1QH, UK
Department of Genetics, Evolution and Bioagents, Institute of Biology, University of Campinas, 13083-862 Campinas, São Paulo, Brazil
Institute of Biomedical Sciences, University of São Paulo, 05508-900 São Paulo, São Paulo, Brazil
Center for Technological Innovations, Evandro Chagas Institute, Ministry of Health, Ananindeua, 67030-000 Pará, Pará, Brazil
Author to whom correspondence should be addressed.
Viruses 2019, 11(3), 297;
Received: 22 January 2019 / Revised: 11 March 2019 / Accepted: 18 March 2019 / Published: 24 March 2019
(This article belongs to the Section Animal Viruses)
PDF [1446 KB, uploaded 24 March 2019]


The Hepacivirus genus comprises single-stranded positive-sense RNA viruses within the family Flaviviridae. Several hepaciviruses have been identified in different mammals, including multiple rodent species in Africa, Asia, Europe, and North America. To date, no rodent hepacivirus has been identified in the South American continent. Here, we describe an unknown hepacivirus discovered during a metagenomic screen in Akodon montensis, Calomys tener, Oligoryzomys nigripes, Necromys lasiurus, and Mus musculus from São Paulo State, Brazil. Molecular detection of this novel hepacivirus by RT-PCR showed a frequency of 11.11% (2/18) in Oligoryzomys nigripes. This is the first identification of hepavivirus in sigmondonine rodents and in rodents from South America. In sum, our results expand the host range, viral diversity, and geographical distribution of the Hepacivirus genus. View Full-Text
Keywords: Viral hepatitis; Hepacivirus; Flaviviridae Viral hepatitis; Hepacivirus; Flaviviridae

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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    Link: http://Table S1, Figure S1 and Figure S2
    Description: Table S1: Percentages of contig assemblies of each pool. Figure S1: Alignment of primer sets region with representative hepacivirus sequences. Figure S2: Mapping of reads against genomes of Oligoryzomys hepacivirus.

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de Souza, W.M.; Fumagalli, M.J.; Sabino-Santos, G., Jr.; Motta Maia, F.G.; Modha, S.; Teixeira Nunes, M.R.; Murcia, P.R.; Moraes Figueiredo, L.T. A Novel Hepacivirus in Wild Rodents from South America. Viruses 2019, 11, 297.

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