Towards Inhaled Phage Therapy in Western Europe
Abstract
:1. Introduction
2. Advantages and Disadvantages of Phage Therapy
2.1. Phage Therapy Provides Several Advantages Over Conventional Antimicrobial Drugs Regarding Medical Application, Some of Which Are Addressed in the Following
2.1.1. Host Specificity and Potential to Spare Microbial Flora
2.1.2. Bacterial Phage Resistance
2.1.3. Self-Replication, Self-Limitation and Anti-Biofilm Properties
2.2. Some of the Disadvantages of Phage Therapy Are Addressed by the Following Aspects
2.2.1. Activity against Intracellular Pathogens
2.2.2. Liberation of Endotoxins
2.2.3. Potential Risk of Anaphylaxis
2.2.4. Immune Response to Phages
3. Challenges in Clinical Use of Phage Therapy
3.1. Current State of Phage Therapy
3.2. Regulatory Challenges
3.3. Production Challenges
3.4. Clincial Trial Challenges and Ongoing Projects
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Wienhold, S.-M.; Lienau, J.; Witzenrath, M. Towards Inhaled Phage Therapy in Western Europe. Viruses 2019, 11, 295. https://doi.org/10.3390/v11030295
Wienhold S-M, Lienau J, Witzenrath M. Towards Inhaled Phage Therapy in Western Europe. Viruses. 2019; 11(3):295. https://doi.org/10.3390/v11030295
Chicago/Turabian StyleWienhold, Sandra-Maria, Jasmin Lienau, and Martin Witzenrath. 2019. "Towards Inhaled Phage Therapy in Western Europe" Viruses 11, no. 3: 295. https://doi.org/10.3390/v11030295