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Viruses 2019, 11(3), 287; https://doi.org/10.3390/v11030287

Non-Pathogenic Mopeia Virus Induces More Robust Activation of Plasmacytoid Dendritic Cells than Lassa Virus

1
Unité de Biologie des Infections Virales Emergentes, Institut Pasteur, 69007 Lyon, France
2
Centre International de Recherche en Infectiologie (INSERM, CNRS, ENS Lyon, Université Lyon I), 69007 Lyon, France
3
Hub de Bioinformatique et Biostatistique–C3BI, Institut Pasteur, USR 3756 CNRS, 75015 Paris, France
*
Author to whom correspondence should be addressed.
Received: 28 January 2019 / Revised: 4 March 2019 / Accepted: 18 March 2019 / Published: 21 March 2019
(This article belongs to the Special Issue Medical Advances in Viral Hemorrhagic Fever Research)
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Abstract

Lassa virus (LASV) causes a viral haemorrhagic fever in humans and is a major public health concern in West Africa. An efficient immune response to LASV appears to rely on type I interferon (IFN-I) production and T-cell activation. We evaluated the response of plasmacytoid dendritic cells (pDC) to LASV, as they are an important and early source of IFN-I. We compared the response of primary human pDCs to LASV and Mopeia virus (MOPV), which is very closely related to LASV, but non-pathogenic. We showed that pDCs are not productively infected by either MOPV or LASV, but produce IFN-I. However, the activation of pDCs was more robust in response to MOPV than LASV. In vivo, pDC activation may support the control of viral replication through IFN-I production, but also improve the induction of a global immune response. Therefore, pDC activation could play a role in the control of LASV infection. View Full-Text
Keywords: Lassa virus; Mopeia virus; viral haemorrhagic fever; plasmacytoid dendritic cells; type I interferon Lassa virus; Mopeia virus; viral haemorrhagic fever; plasmacytoid dendritic cells; type I interferon
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Schaeffer, J.; Reynard, S.; Carnec, X.; Pietrosemoli, N.; Dillies, M.-A.; Baize, S. Non-Pathogenic Mopeia Virus Induces More Robust Activation of Plasmacytoid Dendritic Cells than Lassa Virus. Viruses 2019, 11, 287.

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