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Mechanistic Insights into Chemoresistance Mediated by Oncogenic Viruses in Lymphomas

1
Department of Pathology, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, 4301 W Markham St, Little Rock, AR 72205, USA
2
Department of Biochemistry and Molecular Biology, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, 4301 W Markham St, Little Rock, AR 72205, USA
*
Author to whom correspondence should be addressed.
Viruses 2019, 11(12), 1161; https://doi.org/10.3390/v11121161
Received: 18 November 2019 / Revised: 9 December 2019 / Accepted: 12 December 2019 / Published: 16 December 2019
(This article belongs to the Section Animal Viruses)
Viral lymphomagenesis induced by infection with oncogenic viruses, such as Kaposi’s sarcoma associated herpesvirus (KSHV), Epstein–Barr virus (EBV) and human T-cell leukemia virus (HTLV-1), represents a group of aggressive malignancies with a diverse range of pathological features. Combined chemotherapy remains the standard of care for these virus-associated lymphomas; however, frequent chemoresistance is a barrier to achieving successful long-term disease-free survival. There is increasing evidence that indicates virus-associated lymphomas display more resistance to cytotoxic chemotherapeutic agents than that observed in solid tumors. Although the tumor microenvironment and genetic changes, such as key oncogene mutations, are closely related to chemoresistance, some studies demonstrate that the components of oncogenic viruses themselves play pivotal roles in the multidrug chemoresistance of lymphoma cells. In this review, we summarize recent advances in the understanding of the mechanisms through which oncogenic viruses mediate lymphoma cell chemoresistance, with a particular focus on KSHV and EBV, two major oncogenic viruses. We also discuss the current challenges to overcome these obstacles in the treatment of virus-associated lymphomas. View Full-Text
Keywords: chemoresistance; lymphoma; oncogenic virus; EBV; KSHV chemoresistance; lymphoma; oncogenic virus; EBV; KSHV
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MDPI and ACS Style

Chen, J.; Kendrick, S.; Qin, Z. Mechanistic Insights into Chemoresistance Mediated by Oncogenic Viruses in Lymphomas. Viruses 2019, 11, 1161.

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