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Viruses 2018, 10(8), 392;

Redox Biology of Respiratory Viral Infections

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov str, 32, 119991 Moscow, Russia
Inserm U1052, Cancer Research Center Lyon, University of Lyon, 69000 Lyon, France
DevWeCan Laboratories of Excellence Network (Labex), 69003 Lyon, France
Authors to whom correspondence should be addressed.
Received: 13 June 2018 / Revised: 17 July 2018 / Accepted: 24 July 2018 / Published: 26 July 2018
(This article belongs to the Special Issue What’s New with Flu?)
PDF [1070 KB, uploaded 26 July 2018]


Respiratory viruses cause infections of the upper or lower respiratory tract and they are responsible for the common cold—the most prevalent disease in the world. In many cases the common cold results in severe illness due to complications, such as fever or pneumonia. Children, old people, and immunosuppressed patients are at the highest risk and require fast diagnosis and therapeutic intervention. However, the availability and efficiencies of existing therapeutic approaches vary depending on the virus. Investigation of the pathologies that are associated with infection by respiratory viruses will be paramount for diagnosis, treatment modalities, and the development of new therapies. Changes in redox homeostasis in infected cells are one of the key events that is linked to infection with respiratory viruses and linked to inflammation and subsequent tissue damage. Our review summarizes current knowledge on changes to redox homeostasis, as induced by the different respiratory viruses. View Full-Text
Keywords: oxidative stress; reactive oxygen species; influenza virus; respiratory syncytial virus; rhinovirus; Nrf2; inflammation oxidative stress; reactive oxygen species; influenza virus; respiratory syncytial virus; rhinovirus; Nrf2; inflammation

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Khomich, O.A.; Kochetkov, S.N.; Bartosch, B.; Ivanov, A.V. Redox Biology of Respiratory Viral Infections. Viruses 2018, 10, 392.

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