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Viruses 2018, 10(6), 278; https://doi.org/10.3390/v10060278

Human Metapneumovirus Small Hydrophobic Protein Inhibits Interferon Induction in Plasmacytoid Dendritic Cells

1
Department of Pediatrics, The University of Texas Medical Branch, Galveston, TX 77555, USA
2
Atara Biotherapeutics, Oak Park, CA 94080, USA
3
Adena Health System, Chillicothe, OH 45601, USA
4
Department of Pathology, The University of Texas Medical Branch, Galveston, TX 77555, USA
5
Department of Microbiology & Immunology, The University of Texas Medical Branch, Galveston, TX 77555, USA
6
Sealy Center for Vaccine Development, The University of Texas Medical Branch, Galveston, TX 77555, USA
*
Authors to whom correspondence should be addressed.
Received: 7 May 2018 / Revised: 20 May 2018 / Accepted: 21 May 2018 / Published: 23 May 2018
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Abstract

Human metapneumovirus (hMPV), a leading cause of respiratory tract infections in infants, encodes a small hydrophobic (SH) protein of unknown function. Here we show that infection of plasmacytoid dendritic cells (pDCs) with a recombinant virus lacking SH expression (rhMPV-ΔSH) enhanced the secretion of type I interferons (IFNs), which required TLR7 and MyD88 expression. HMPV SH protein inhibited TLR7/MyD88/TRAF6 signaling leading to IFN gene transcription, identifying a novel mechanism by which paramyxovirus SH proteins modulate innate immune responses. View Full-Text
Keywords: hMPV; SH protein; plasmacytoid dendritic cells; type I IFN hMPV; SH protein; plasmacytoid dendritic cells; type I IFN
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Bao, X.; Kolli, D.; Esham, D.; Velayutham, T.S.; Casola, A. Human Metapneumovirus Small Hydrophobic Protein Inhibits Interferon Induction in Plasmacytoid Dendritic Cells. Viruses 2018, 10, 278.

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