Next Article in Journal
Characterization of NS5A and NS5B Resistance-Associated Substitutions from Genotype 1 Hepatitis C Virus Infected Patients in a Portuguese Cohort
Previous Article in Journal
Within-Host Recombination in the Foot-and-Mouth Disease Virus Genome
Article Menu
Issue 5 (May) cover image

Export Article

Open AccessReview
Viruses 2018, 10(5), 222; https://doi.org/10.3390/v10050222

A Systematic Review of the Natural Virome of Anopheles Mosquitoes

1
Institut Pasteur, Unit of Genetics and Genomics of Insect Vectors, Department of Parasites and Insect Vectors, 28 rue du Docteur Roux, 75015 Paris, France
2
CNRS, Unit of Evolutionary Genomics, Modeling and Health (UMR2000), 28 rue du Docteur Roux, 75015 Paris, France
3
Graduate School of Life Sciences ED515, Sorbonne Universities, UPMC Paris VI, 75252 Paris, France
*
Author to whom correspondence should be addressed.
Received: 7 April 2018 / Revised: 20 April 2018 / Accepted: 21 April 2018 / Published: 25 April 2018
(This article belongs to the Section Insect Viruses)
Full-Text   |   PDF [857 KB, uploaded 3 May 2018]   |  

Abstract

Anopheles mosquitoes are vectors of human malaria, but they also harbor viruses, collectively termed the virome. The Anopheles virome is relatively poorly studied, and the number and function of viruses are unknown. Only the o’nyong-nyong arbovirus (ONNV) is known to be consistently transmitted to vertebrates by Anopheles mosquitoes. A systematic literature review searched four databases: PubMed, Web of Science, Scopus, and Lissa. In addition, online and print resources were searched manually. The searches yielded 259 records. After screening for eligibility criteria, we found at least 51 viruses reported in Anopheles, including viruses with potential to cause febrile disease if transmitted to humans or other vertebrates. Studies to date have not provided evidence that Anopheles consistently transmit and maintain arboviruses other than ONNV. However, anthropophilic Anopheles vectors of malaria are constantly exposed to arboviruses in human bloodmeals. It is possible that in malaria-endemic zones, febrile symptoms may be commonly misdiagnosed. It is also possible that anophelines may be inherently less competent arbovirus vectors than culicines, but if true, the biological basis would warrant further study. This systematic review contributes a context to characterize the biology, knowledge gaps, and potential public health risk of Anopheles viruses. View Full-Text
Keywords: insect vectors; virome; arbovirus; insect immunity; host–pathogen interactions; malaria insect vectors; virome; arbovirus; insect immunity; host–pathogen interactions; malaria
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Nanfack Minkeu, F.; Vernick, K.D. A Systematic Review of the Natural Virome of Anopheles Mosquitoes. Viruses 2018, 10, 222.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top