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Viruses 2018, 10(5), 222;

A Systematic Review of the Natural Virome of Anopheles Mosquitoes

Institut Pasteur, Unit of Genetics and Genomics of Insect Vectors, Department of Parasites and Insect Vectors, 28 rue du Docteur Roux, 75015 Paris, France
CNRS, Unit of Evolutionary Genomics, Modeling and Health (UMR2000), 28 rue du Docteur Roux, 75015 Paris, France
Graduate School of Life Sciences ED515, Sorbonne Universities, UPMC Paris VI, 75252 Paris, France
Author to whom correspondence should be addressed.
Received: 7 April 2018 / Revised: 20 April 2018 / Accepted: 21 April 2018 / Published: 25 April 2018
(This article belongs to the Section Insect Viruses)
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Anopheles mosquitoes are vectors of human malaria, but they also harbor viruses, collectively termed the virome. The Anopheles virome is relatively poorly studied, and the number and function of viruses are unknown. Only the o’nyong-nyong arbovirus (ONNV) is known to be consistently transmitted to vertebrates by Anopheles mosquitoes. A systematic literature review searched four databases: PubMed, Web of Science, Scopus, and Lissa. In addition, online and print resources were searched manually. The searches yielded 259 records. After screening for eligibility criteria, we found at least 51 viruses reported in Anopheles, including viruses with potential to cause febrile disease if transmitted to humans or other vertebrates. Studies to date have not provided evidence that Anopheles consistently transmit and maintain arboviruses other than ONNV. However, anthropophilic Anopheles vectors of malaria are constantly exposed to arboviruses in human bloodmeals. It is possible that in malaria-endemic zones, febrile symptoms may be commonly misdiagnosed. It is also possible that anophelines may be inherently less competent arbovirus vectors than culicines, but if true, the biological basis would warrant further study. This systematic review contributes a context to characterize the biology, knowledge gaps, and potential public health risk of Anopheles viruses. View Full-Text
Keywords: insect vectors; virome; arbovirus; insect immunity; host–pathogen interactions; malaria insect vectors; virome; arbovirus; insect immunity; host–pathogen interactions; malaria

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Nanfack Minkeu, F.; Vernick, K.D. A Systematic Review of the Natural Virome of Anopheles Mosquitoes. Viruses 2018, 10, 222.

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