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Enterovirus Transmission by Secretory Autophagy

Laboratory of Host-Pathogen Dynamics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
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Viruses 2018, 10(3), 139; https://doi.org/10.3390/v10030139
Received: 6 February 2018 / Revised: 12 March 2018 / Accepted: 16 March 2018 / Published: 20 March 2018
(This article belongs to the Special Issue Viruses and Autophagy)
Present in many cell types, non-degradative secretory autophagy is a newly discovered pathway in which autophagosomes fuse with the plasma membrane instead of lysosomes. Surprisingly, some viruses exploit secretory autophagy to exit cells non-lytically, shedding into the extracellular environment as particle populations contained within vesicles. As a result, this significantly enhances the infectivity of these viruses. In this paper, this novel cellular exit pathway is highlighted and its advantages for viral transmission discussed. View Full-Text
Keywords: secretory autophagy; picornavirus; enterovirus; poliovirus; Coxsackievirus; rhinovirus; syntaxin 17; viral transmission; quasispecies; RNA virus secretory autophagy; picornavirus; enterovirus; poliovirus; Coxsackievirus; rhinovirus; syntaxin 17; viral transmission; quasispecies; RNA virus
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Mutsafi, Y.; Altan-Bonnet, N. Enterovirus Transmission by Secretory Autophagy. Viruses 2018, 10, 139.

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