Stem Cell-Derived Models of Viral Infections in the Gastrointestinal Tract
Abstract
:1. Introduction
2. Defining Gastrointestinal Models
3. Development of Mini-Intestinal Models
3.1. Enteroid Development
3.2. Organoid Development
4. Mini-Intestinal Differentiation and Morphology
4.1. Region-Specific Differentiation
4.2. Crypt-Villus Development
4.3. Cell Types within Crypts
5. In Vitro Models to Study Viral Infections
5.1. Human Intestinal Organoids to Model Rotaviral Infections
5.2. Human Intestinal Enteroids to Model Rotaviral Infection
5.3. Cultivating Norovirus in Human Intestinal Enteroids
5.4. Enteroids as a Model of Enterovirus Infection
5.5. Enteroid Model of Adenoviral Infection
6. Conclusions and Future Directions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Lanik, W.E.; Mara, M.A.; Mihi, B.; Coyne, C.B.; Good, M. Stem Cell-Derived Models of Viral Infections in the Gastrointestinal Tract. Viruses 2018, 10, 124. https://doi.org/10.3390/v10030124
Lanik WE, Mara MA, Mihi B, Coyne CB, Good M. Stem Cell-Derived Models of Viral Infections in the Gastrointestinal Tract. Viruses. 2018; 10(3):124. https://doi.org/10.3390/v10030124
Chicago/Turabian StyleLanik, Wyatt E., Madison A. Mara, Belgacem Mihi, Carolyn B. Coyne, and Misty Good. 2018. "Stem Cell-Derived Models of Viral Infections in the Gastrointestinal Tract" Viruses 10, no. 3: 124. https://doi.org/10.3390/v10030124