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Viruses 2018, 10(11), 593; https://doi.org/10.3390/v10110593

Research Models and Tools for the Identification of Antivirals and Therapeutics against Zika Virus Infection

1
Institute of Virology and Immunology, 3012 Bern, Switzerland
2
Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland
3
Graduate School for Cellular and Biomedical Sciences, University of Bern, 3012 Bern, Switzerland
*
Authors to whom correspondence should be addressed.
Received: 2 October 2018 / Revised: 24 October 2018 / Accepted: 26 October 2018 / Published: 30 October 2018
(This article belongs to the Special Issue New Advances on Zika Virus Research)
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Abstract

Zika virus recently re-emerged and caused global outbreaks mainly in Central Africa, Southeast Asia, the Pacific Islands and in Central and South America. Even though there is a declining trend, the virus continues to spread throughout different geographical regions of the world. Since its re-emergence in 2015, massive advances have been made regarding our understanding of clinical manifestations, epidemiology, genetic diversity, genomic structure and potential therapeutic intervention strategies. Nevertheless, treatment remains a challenge as there is no licensed effective therapy available. This review focuses on the recent advances regarding research models, as well as available experimental tools that can be used for the identification and characterization of potential antiviral targets and therapeutic intervention strategies. View Full-Text
Keywords: Zika virus; antivirals; therapeutics; research models and tools Zika virus; antivirals; therapeutics; research models and tools
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Alves, M.P.; Vielle, N.J.; Thiel, V.; Pfaender, S. Research Models and Tools for the Identification of Antivirals and Therapeutics against Zika Virus Infection. Viruses 2018, 10, 593.

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