Next Article in Journal
Impact of Two Reoviruses and Their Coinfection on the Rice RNAi System and vsiRNA Production
Next Article in Special Issue
Reverse Genetic Approaches for the Generation of Recombinant Zika Virus
Previous Article in Journal
Silvestrol Inhibits Chikungunya Virus Replication
Previous Article in Special Issue
Strain-Dependent Consequences of Zika Virus Infection and Differential Impact on Neural Development
Article Menu
Issue 11 (November) cover image

Export Article

Open AccessReview
Viruses 2018, 10(11), 593;

Research Models and Tools for the Identification of Antivirals and Therapeutics against Zika Virus Infection

Institute of Virology and Immunology, 3012 Bern, Switzerland
Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland
Graduate School for Cellular and Biomedical Sciences, University of Bern, 3012 Bern, Switzerland
Authors to whom correspondence should be addressed.
Received: 2 October 2018 / Revised: 24 October 2018 / Accepted: 26 October 2018 / Published: 30 October 2018
(This article belongs to the Special Issue New Advances on Zika Virus Research)
PDF [2763 KB, uploaded 30 October 2018]


Zika virus recently re-emerged and caused global outbreaks mainly in Central Africa, Southeast Asia, the Pacific Islands and in Central and South America. Even though there is a declining trend, the virus continues to spread throughout different geographical regions of the world. Since its re-emergence in 2015, massive advances have been made regarding our understanding of clinical manifestations, epidemiology, genetic diversity, genomic structure and potential therapeutic intervention strategies. Nevertheless, treatment remains a challenge as there is no licensed effective therapy available. This review focuses on the recent advances regarding research models, as well as available experimental tools that can be used for the identification and characterization of potential antiviral targets and therapeutic intervention strategies. View Full-Text
Keywords: Zika virus; antivirals; therapeutics; research models and tools Zika virus; antivirals; therapeutics; research models and tools

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
Printed Edition Available!
A printed edition of this Special Issue is available here.

Share & Cite This Article

MDPI and ACS Style

Alves, M.P.; Vielle, N.J.; Thiel, V.; Pfaender, S. Research Models and Tools for the Identification of Antivirals and Therapeutics against Zika Virus Infection. Viruses 2018, 10, 593.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top