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Open AccessCommunication

Time to Harmonize Dengue Nomenclature and Classification

Department of Microbiology and Immunology, Rega Institute for Medical Research, Clinical and Epidemiological Virology, KU Leuven, 3000 Leuven, Belgium
Nuffield Department of Medicine, University of Oxford, Oxford OX1 3SY, UK
Artificial Intelligence Lab, Department of Computer Science, Vrije Universiteit Brussel, 1050 Brussels, Belgium
Division of Vector-Borne Diseases, Dengue Branch, Centers for Disease Control and Prevention, San Juan, PR 00920, USA
Laboratório de Flavivírus, Instituto Oswaldo Cruz, FIOCRUZ, 21040-360 Rio de Janeiro, Brazil
Global Health and Tropical Medicine, Unidade de Microbiologia, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, 1349-008 Lisbon, Portugal
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Viruses 2018, 10(10), 569;
Received: 14 September 2018 / Revised: 5 October 2018 / Accepted: 15 October 2018 / Published: 18 October 2018
Dengue virus (DENV) is estimated to cause 390 million infections per year worldwide. A quarter of these infections manifest clinically and are associated with a morbidity and mortality that put a significant burden on the affected regions. Reports of increased frequency, intensity, and extended geographical range of outbreaks highlight the virus’s ongoing global spread. Persistent transmission in endemic areas and the emergence in territories formerly devoid of transmission have shaped DENV’s current genetic diversity and divergence. This genetic layout is hierarchically organized in serotypes, genotypes, and sub-genotypic clades. While serotypes are well defined, the genotype nomenclature and classification system lack consistency, which complicates a broader analysis of their clinical and epidemiological characteristics. We identify five key challenges: (1) Currently, there is no formal definition of a DENV genotype; (2) Two different nomenclature systems are used in parallel, which causes significant confusion; (3) A standardized classification procedure is lacking so far; (4) No formal definition of sub-genotypic clades is in place; (5) There is no consensus on how to report antigenic diversity. Therefore, we believe that the time is right to re-evaluate DENV genetic diversity in an essential effort to provide harmonization across DENV studies. View Full-Text
Keywords: dengue virus; classification; nomenclature; diversity dengue virus; classification; nomenclature; diversity
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Cuypers, L.; Libin, P.J.K.; Simmonds, P.; Nowé, A.; Muñoz-Jordán, J.; Alcantara, L.C.J.; Vandamme, A.-M.; Santiago, G.A.; Theys, K. Time to Harmonize Dengue Nomenclature and Classification. Viruses 2018, 10, 569.

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