Next Article in Journal
Role of Host Cell Secretory Machinery in Zika Virus Life Cycle
Previous Article in Journal
Bowman‒Birk Inhibitor Suppresses Herpes Simplex Virus Type 2 Infection of Human Cervical Epithelial Cells
Brief Report

Systemic Administration and Targeted Delivery of Immunogenic Oncolytic Adenovirus Encapsulated in Extracellular Vesicles for Cancer Therapies

1
Department of Oncology and Hemato-Oncology, Center of Excellence on Neurodegenerative Diseases, University of Milan, 20122 Milan, Italy
2
Center of Excellence on Neurodegenerative Diseases, University of Milan, 20133 Milan, Italy
3
Targovax Oy, Clinical Science, 00180 Helsinki, Finland
4
Department of Virology, National Institute of Public Health—National Institute of Hygiene, 00-791 Warsaw, Poland
5
Gastrointestinal Surgery and Liver Transplantation Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy
*
Authors to whom correspondence should be addressed.
Viruses 2018, 10(10), 558; https://doi.org/10.3390/v10100558
Received: 2 October 2018 / Accepted: 11 October 2018 / Published: 13 October 2018
(This article belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Oncolytic viruses (OV) are engineered to infect, replicate in and kill cancer cells. Currently, the OV therapeutic approach is mainly restricted to neoplasia amenable to direct local administration of viral particles, while the possibility of a systemic delivery of cancer-tropic viruses would extend the OV application to the treatment of metastatic neoplasia. Herein, we applied in vivo/ex vivo imaging to demonstrate that cancer tropism is achieved when OV are encapsulated inside extracellular vesicles (EV) administered intravenously (i.v.), but not when injected intraperitoneally (i.p.). Moreover, we show that the therapeutic procedure adopted does not alter the immunomodulatory properties of the viruses. View Full-Text
Keywords: Oncolytic adenovirus; extracellular vesicles; lung cancer; immunocompetent mouse model; in vivo imaging Oncolytic adenovirus; extracellular vesicles; lung cancer; immunocompetent mouse model; in vivo imaging
Show Figures

Figure 1

MDPI and ACS Style

Garofalo, M.; Villa, A.; Rizzi, N.; Kuryk, L.; Mazzaferro, V.; Ciana, P. Systemic Administration and Targeted Delivery of Immunogenic Oncolytic Adenovirus Encapsulated in Extracellular Vesicles for Cancer Therapies. Viruses 2018, 10, 558. https://doi.org/10.3390/v10100558

AMA Style

Garofalo M, Villa A, Rizzi N, Kuryk L, Mazzaferro V, Ciana P. Systemic Administration and Targeted Delivery of Immunogenic Oncolytic Adenovirus Encapsulated in Extracellular Vesicles for Cancer Therapies. Viruses. 2018; 10(10):558. https://doi.org/10.3390/v10100558

Chicago/Turabian Style

Garofalo, Mariangela, Alessandro Villa, Nicoletta Rizzi, Lukasz Kuryk, Vincenzo Mazzaferro, and Paolo Ciana. 2018. "Systemic Administration and Targeted Delivery of Immunogenic Oncolytic Adenovirus Encapsulated in Extracellular Vesicles for Cancer Therapies" Viruses 10, no. 10: 558. https://doi.org/10.3390/v10100558

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop