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Viruses 2018, 10(10), 558; https://doi.org/10.3390/v10100558 (registering DOI)

Systemic Administration and Targeted Delivery of Immunogenic Oncolytic Adenovirus Encapsulated in Extracellular Vesicles for Cancer Therapies

1
Department of Oncology and Hemato-Oncology, Center of Excellence on Neurodegenerative Diseases, University of Milan, 20122 Milan, Italy
2
Center of Excellence on Neurodegenerative Diseases, University of Milan, 20133 Milan, Italy
3
Targovax Oy, Clinical Science, 00180 Helsinki, Finland
4
Department of Virology, National Institute of Public Health—National Institute of Hygiene, 00-791 Warsaw, Poland
5
Gastrointestinal Surgery and Liver Transplantation Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy
*
Authors to whom correspondence should be addressed.
Received: 2 October 2018 / Accepted: 11 October 2018 / Published: 13 October 2018
(This article belongs to the Section Antivirals & Vaccines)
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Abstract

Oncolytic viruses (OV) are engineered to infect, replicate in and kill cancer cells. Currently, the OV therapeutic approach is mainly restricted to neoplasia amenable to direct local administration of viral particles, while the possibility of a systemic delivery of cancer-tropic viruses would extend the OV application to the treatment of metastatic neoplasia. Herein, we applied in vivo/ex vivo imaging to demonstrate that cancer tropism is achieved when OV are encapsulated inside extracellular vesicles (EV) administered intravenously (i.v.), but not when injected intraperitoneally (i.p.). Moreover, we show that the therapeutic procedure adopted does not alter the immunomodulatory properties of the viruses. View Full-Text
Keywords: Oncolytic adenovirus; extracellular vesicles; lung cancer; immunocompetent mouse model; in vivo imaging Oncolytic adenovirus; extracellular vesicles; lung cancer; immunocompetent mouse model; in vivo imaging
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Garofalo, M.; Villa, A.; Rizzi, N.; Kuryk, L.; Mazzaferro, V.; Ciana, P. Systemic Administration and Targeted Delivery of Immunogenic Oncolytic Adenovirus Encapsulated in Extracellular Vesicles for Cancer Therapies. Viruses 2018, 10, 558.

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