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Volume 10
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10.3390/v10100557
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Article

Bowman‒Birk Inhibitor Suppresses Herpes Simplex Virus Type 2 Infection of Human Cervical Epithelial Cells

by
Yu Liu
1,
Xi-Qiu Xu
1,
Biao Zhang
1,
Jun Gu
1,
Feng-Zhen Meng
1,
Hang Liu
1,
Li Zhou
1,
Xu Wang
2,
Wei Hou
1 and
Wen-Zhe Ho
1,2,*
1
School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China
2
Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
*
Author to whom correspondence should be addressed.
Viruses 2018, 10(10), 557; https://doi.org/10.3390/v10100557
Received: 29 August 2018 / Revised: 9 October 2018 / Accepted: 10 October 2018 / Published: 12 October 2018
(This article belongs to the Special Issue Recent Advances of Natural Products in HSV Research)
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Abstract

The Bowman‒Birk inhibitor (BBI), a protease inhibitor derived from soybeans, has been extensively studied in anti-tumor and anti-inflammation research. We recently reported that BBI has an anti-HIV-1 property in primary human macrophages. Because HSV-2 infection plays a role in facilitating HIV-1 sexual transmission, we thus examined whether BBI has the ability to inhibit HSV-2 infection. We demonstrated that BBI could potently inhibit HSV-2 replication in human cervical epithelial cells (End1/E6E7). This BBI-mediated HSV-2 inhibition was partially through blocking HSV-2-mediated activation of NF-κB and p38 MAPK pathways. In addition, BBI could activate the JAK/STAT pathway and enhance the expression of several antiviral interferon-stimulated genes (ISGs). Furthermore, BBI treatment of End1/E6E7 cells upregulated the expression of tight junction proteins and reduced HSV-2-mediated cellular ubiquitinated proteins’ degradation through suppressing the ubiquitin‒proteasome system. These observations indicate that BBI may have therapeutic potential for the prevention and treatment of HSV-2 infections. View Full-Text
Keywords: Bowman‒Birk inhibitor (BBI); herpes simplex virus type 2 (HSV-2); antiviral activity; NF-κB; ubiquitin‒proteasome system (UPS); antiviral ISGs Bowman‒Birk inhibitor (BBI); herpes simplex virus type 2 (HSV-2); antiviral activity; NF-κB; ubiquitin‒proteasome system (UPS); antiviral ISGs
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MDPI and ACS Style

Liu, Y.; Xu, X.-Q.; Zhang, B.; Gu, J.; Meng, F.-Z.; Liu, H.; Zhou, L.; Wang, X.; Hou, W.; Ho, W.-Z. Bowman‒Birk Inhibitor Suppresses Herpes Simplex Virus Type 2 Infection of Human Cervical Epithelial Cells. Viruses 2018, 10, 557. https://doi.org/10.3390/v10100557

AMA Style

Liu Y, Xu X-Q, Zhang B, Gu J, Meng F-Z, Liu H, Zhou L, Wang X, Hou W, Ho W-Z. Bowman‒Birk Inhibitor Suppresses Herpes Simplex Virus Type 2 Infection of Human Cervical Epithelial Cells. Viruses. 2018; 10(10):557. https://doi.org/10.3390/v10100557

Chicago/Turabian Style

Liu, Yu, Xi-Qiu Xu, Biao Zhang, Jun Gu, Feng-Zhen Meng, Hang Liu, Li Zhou, Xu Wang, Wei Hou, and Wen-Zhe Ho. 2018. "Bowman‒Birk Inhibitor Suppresses Herpes Simplex Virus Type 2 Infection of Human Cervical Epithelial Cells" Viruses 10, no. 10: 557. https://doi.org/10.3390/v10100557

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