Next Article in Journal / Special Issue
Therapeutic Approaches Using Host Defence Peptides to Tackle Herpes Virus Infections
Previous Article in Journal
Protection against Mucosal SHIV Challenge by Peptide and Helper-Dependent Adenovirus Vaccines
Previous Article in Special Issue
The Human Cytomegalovirus Major Immediate-Early Proteins as Antagonists of Intrinsic and Innate Antiviral Host Responses
Open AccessReview

Cellular Players in the Herpes Simplex Virus Dependent Apoptosis Balancing Act

1
Department of Microbiology and Immunology, Des Moines University, Des Moines, IA, USA
2
Department of Microbiology, Mount Sinai School of Medicine, New York, NY, USA
*
Author to whom correspondence should be addressed.
Viruses 2009, 1(3), 965-978; https://doi.org/10.3390/v1030965
Received: 30 September 2009 / Revised: 16 November 2009 / Accepted: 17 November 2009 / Published: 18 November 2009
(This article belongs to the Special Issue Antiviral Responses to Herpes Viruses)
Apoptosis is triggered as an intrinsic defense against numerous viral infections. Almost every virus encodes apoptotic modulators, and the herpes simplex viruses (HSV) are no exception. During HSV infection, there is an intricate balance between pro- and anti-apoptotic factors that delays apoptotic death until the virus has replicated. Perturbations in the apoptotic balance can cause premature cell death and have the potential to dramatically alter the outcome of infection. Recently, certain cellular genes have been shown to regulate sensitivity to HSV-dependent apoptosis. This review summarizes current knowledge of the cellular genes that impact the apoptotic balance during HSV infection. View Full-Text
Keywords: Herpes Simplex Virus; apoptosis; virus-host interactions Herpes Simplex Virus; apoptosis; virus-host interactions
Show Figures

Graphical abstract

MDPI and ACS Style

Nguyen, M.L.; Blaho, J.A. Cellular Players in the Herpes Simplex Virus Dependent Apoptosis Balancing Act. Viruses 2009, 1, 965-978.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Search more from Scilit
 
Search
Back to TopTop