Next Article in Journal / Special Issue
Therapeutic Approaches Using Host Defence Peptides to Tackle Herpes Virus Infections
Previous Article in Journal
Protection against Mucosal SHIV Challenge by Peptide and Helper-Dependent Adenovirus Vaccines
Previous Article in Special Issue
The Human Cytomegalovirus Major Immediate-Early Proteins as Antagonists of Intrinsic and Innate Antiviral Host Responses
Article Menu

Export Article

Open AccessReview
Viruses 2009, 1(3), 965-978;

Cellular Players in the Herpes Simplex Virus Dependent Apoptosis Balancing Act

Department of Microbiology and Immunology, Des Moines University, Des Moines, IA, USA
Department of Microbiology, Mount Sinai School of Medicine, New York, NY, USA
Author to whom correspondence should be addressed.
Received: 30 September 2009 / Revised: 16 November 2009 / Accepted: 17 November 2009 / Published: 18 November 2009
(This article belongs to the Special Issue Antiviral Responses to Herpes Viruses)
Full-Text   |   PDF [239 KB, uploaded 12 May 2015]   |  


Apoptosis is triggered as an intrinsic defense against numerous viral infections. Almost every virus encodes apoptotic modulators, and the herpes simplex viruses (HSV) are no exception. During HSV infection, there is an intricate balance between pro- and anti-apoptotic factors that delays apoptotic death until the virus has replicated. Perturbations in the apoptotic balance can cause premature cell death and have the potential to dramatically alter the outcome of infection. Recently, certain cellular genes have been shown to regulate sensitivity to HSV-dependent apoptosis. This review summarizes current knowledge of the cellular genes that impact the apoptotic balance during HSV infection. View Full-Text
Keywords: Herpes Simplex Virus; apoptosis; virus-host interactions Herpes Simplex Virus; apoptosis; virus-host interactions

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Nguyen, M.L.; Blaho, J.A. Cellular Players in the Herpes Simplex Virus Dependent Apoptosis Balancing Act. Viruses 2009, 1, 965-978.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top