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Therapeutic Approaches Using Host Defence Peptides to Tackle Herpes Virus Infections

Department of Science, Systems & Models, Roskilde University, Universitetsvej 1, Building 18.1, DK-4000 Roskilde, Denmark
Viruses 2009, 1(3), 939-964; https://doi.org/10.3390/v1030939
Received: 24 July 2009 / Revised: 11 October 2009 / Accepted: 16 November 2009 / Published: 18 November 2009
(This article belongs to the Special Issue Antiviral Responses to Herpes Viruses)
One of the most common viral infections in humans is caused by herpes simplex virus (HSV). It can easily be treated with nucleoside analogues (e.g., acyclovir), but resistant strains are on the rise. Naturally occurring antimicrobial peptides have been demonstrated to possess antiviral activity against HSV. New evidence has also indicated that these host defence peptides are able to selectively stimulate the innate immune system to fight of infections. This review will focus on the anti-HSV activity of such peptides (both natural and synthetic), describe their mode of action and their clinical potential. View Full-Text
Keywords: cationic host defence peptides; antiviral therapy; herpes; antimicrobial peptides; innate defense regulators; immune stimulation cationic host defence peptides; antiviral therapy; herpes; antimicrobial peptides; innate defense regulators; immune stimulation
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Jenssen, H. Therapeutic Approaches Using Host Defence Peptides to Tackle Herpes Virus Infections. Viruses 2009, 1, 939-964.

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