Next Article in Journal
Liver Cell Transformation in Chronic HBV Infection
Next Article in Special Issue
Viral Hybrid Vectors for Somatic Integration - Are They the Better Solution?
Previous Article in Journal
Antagonism of Innate Immunity by Paramyxovirus Accessory Proteins
Previous Article in Special Issue
Alphaviruses in Gene Therapy
Open AccessReview

Herpes Virus Amplicon Vectors

by Suresh De Silva 1,2,3 and William J. Bowers 2,3,4,5,*
1
Department of Biochemistry and Biophysics, University of Rochester, Rochester, NY 14642, USA
2
Center for Neural Development and Disease, University of Rochester, Rochester, NY 14642, USA
3
School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
4
Department of Neurology, University of Rochester, Rochester, NY 14642, USA
5
Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA
*
Author to whom correspondence should be addressed.
Viruses 2009, 1(3), 594-629; https://doi.org/10.3390/v1030594
Received: 30 September 2009 / Revised: 26 October 2009 / Accepted: 29 October 2009 / Published: 29 October 2009
(This article belongs to the Special Issue Novel Viral Vector Systems for Gene Therapy)
Since its emergence onto the gene therapy scene nearly 25 years ago, the replication-defective Herpes Simplex Virus Type-1 (HSV-1) amplicon has gained significance as a versatile gene transfer platform due to its extensive transgene capacity, widespread cellular tropism, minimal immunogenicity, and its amenability to genetic manipulation. Herein, we detail the recent advances made with respect to the design of the HSV amplicon, its numerous in vitro and in vivo applications, and the current impediments this virus-based gene transfer platform faces as it navigates a challenging path towards future clinical testing. View Full-Text
Keywords: herpes simplex virus; HSV amplicon; gene transfer; immunotherapy; integration herpes simplex virus; HSV amplicon; gene transfer; immunotherapy; integration
Show Figures

Figure 1

MDPI and ACS Style

De Silva, S.; Bowers, W.J. Herpes Virus Amplicon Vectors. Viruses 2009, 1, 594-629.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Search more from Scilit
 
Search
Back to TopTop