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Adaptive Immunity to Hepatitis C Virus

Inserm, U748, 3 rue Koeberlé, F-67000 Strasbourg, France
Institut de Virologie, Université de Strasbourg, 3 rue Koeberlé, F-67000 Strasbourg, France
Pôle Hépato-Digestif, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, 1 Place de l’Hôpital, F-67000 Strasbourg, France
Author to whom correspondence should be addressed.
Viruses 2009, 1(2), 276-297;
Received: 3 July 2009 / Revised: 14 August 2009 / Accepted: 25 August 2009 / Published: 8 September 2009
(This article belongs to the Special Issue Hepatitis Viruses)
The precise role of adaptive immune responses in the clinical outcome of HCV infection is still only partially defined. Recent studies suggest that viral-host cell interactions during the acute phase of infection are essential for viral clearance or progression into chronic HCV infection. This review focuses on different aspects of the adaptive immune responses as determinants of the different outcomes of HCV infection, clearance or persistent infection, and outlines current concepts of HCV evasion strategies. Unravelling these important mechanisms of virus-host interaction will contribute to the development of novel strategies to prevent and control HCV infection. View Full-Text
Keywords: viral clearance; neutralizing antibodies; T cells; escape; vaccine development viral clearance; neutralizing antibodies; T cells; escape; vaccine development
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Zeisel, M.B.; Fafi-Kremer, S.; Robinet, E.; Habersetzer, F.; Baumert, T.F.; Stoll-Keller, F. Adaptive Immunity to Hepatitis C Virus. Viruses 2009, 1, 276-297.

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