Next Article in Journal
Negative Thermal Expansion in Ba0.5Sr0.5Zn2SiGeO7
Next Article in Special Issue
Photocatalytic, Antimicrobial and Biocompatibility Features of Cotton Knit Coated with Fe-N-Doped Titanium Dioxide Nanoparticles
Previous Article in Journal
Micromechanical Modeling of Fiber-Reinforced Composites with Statistically Equivalent Random Fiber Distribution
Previous Article in Special Issue
Morphological and Structural Study of a Novel Porous Nurse’s A Ceramic with Osteoconductive Properties for Tissue Engineering
Open AccessReview

Electrospun Scaffolds for Corneal Tissue Engineering: A Review

by Bin Kong 1,2 and Shengli Mi 1,3,*
Biomanufacturing Engineering Laboratory, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China
Macromolecular Platforms for Translational Medicine and Bio-Manufacturing Laboratory, Tsinghua-Berkeley Shenzhen Insititute, Shenzhen 518055, China
Open FIESTA Center, Tsinghua University, Shenzhen 518055, China
Author to whom correspondence should be addressed.
Academic Editor: Alina Maria Holban
Materials 2016, 9(8), 614;
Received: 1 June 2016 / Revised: 30 June 2016 / Accepted: 4 July 2016 / Published: 27 July 2016
(This article belongs to the Special Issue Materials for Hard and Soft Tissue Engineering: Novel Approaches)
Corneal diseases constitute the second leading cause of vision loss and affect more than 10 million people globally. As there is a severe shortage of fresh donated corneas and an unknown risk of immune rejection with traditional heterografts, it is very important and urgent to construct a corneal equivalent to replace pathologic corneal tissue. Corneal tissue engineering has emerged as a practical strategy to develop corneal tissue substitutes, and the design of a scaffold with mechanical properties and transparency similar to that of natural cornea is paramount for the regeneration of corneal tissues. Nanofibrous scaffolds produced by electrospinning have high surface area–to-volume ratios and porosity that simulate the structure of protein fibers in native extra cellular matrix (ECM). The versatilities of electrospinning of polymer components, fiber structures, and functionalization have made the fabrication of nanofibrous scaffolds with suitable mechanical strength, transparency and biological properties for corneal tissue engineering feasible. In this paper, we review the recent developments of electrospun scaffolds for engineering corneal tissues, mainly including electrospun materials (single and blended polymers), fiber structures (isotropic or anisotropic), functionalization (improved mechanical properties and transparency), applications (corneal cell survival, maintenance of phenotype and formation of corneal tissue) and future development perspectives. View Full-Text
Keywords: corneal tissue; electrospinning; nanofibrous scaffold; polymer corneal tissue; electrospinning; nanofibrous scaffold; polymer
Show Figures

Graphical abstract

MDPI and ACS Style

Kong, B.; Mi, S. Electrospun Scaffolds for Corneal Tissue Engineering: A Review. Materials 2016, 9, 614.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop