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Materials 2016, 9(6), 443;

Hydrogels as a Replacement Material for Damaged Articular Hyaline Cartilage

School of Oral and Dental Sciences, University of Bristol, Lower Maudlin Street, Bristol BS1 2LY, UK
Musculoskeletal Research Unit, University of Bristol, Level 1 Learning and Research Building, Bristol BS10 5NB, UK
School of Chemistry, University of Bristol, Cantock’s Close, Bristol BS8 1TS, UK
Author to whom correspondence should be addressed.
Academic Editor: Franz E. Weber
Received: 5 May 2016 / Revised: 24 May 2016 / Accepted: 30 May 2016 / Published: 3 June 2016
(This article belongs to the Section Biomaterials)
Full-Text   |   PDF [1479 KB, uploaded 3 June 2016]   |  


Hyaline cartilage is a strong durable material that lubricates joint movement. Due to its avascular structure, cartilage has a poor self-healing ability, thus, a challenge in joint recovery. When severely damaged, cartilage may need to be replaced. However, currently we are unable to replicate the hyaline cartilage, and as such, alternative materials with considerably different properties are used. This results in undesirable side effects, including inadequate lubrication, wear debris, wear of the opposing articular cartilage, and weakening of the surrounding tissue. With the number of surgeries for cartilage repair increasing, a need for materials that can better mimic cartilage, and support the surrounding material in its typical function, is becoming evident. Here, we present a brief overview of the structure and properties of the hyaline cartilage and the current methods for cartilage repair. We then highlight some of the alternative materials under development as potential methods of repair; this is followed by an overview of the development of tough hydrogels. In particular, double network (DN) hydrogels are a promising replacement material, with continually improving physical properties. These hydrogels are coming closer to replicating the strength and toughness of the hyaline cartilage, while offering excellent lubrication. We conclude by highlighting several different methods of integrating replacement materials with the native joint to ensure stability and optimal behaviour. View Full-Text
Keywords: articular cartilage; hydrogels; self-healing; implant; double network articular cartilage; hydrogels; self-healing; implant; double network

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Beddoes, C.M.; Whitehouse, M.R.; Briscoe, W.H.; Su, B. Hydrogels as a Replacement Material for Damaged Articular Hyaline Cartilage. Materials 2016, 9, 443.

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