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Open AccessArticle

Inhibition of Cariogenic Plaque Formation on Root Surface with Polydopamine-Induced-Polyethylene Glycol Coating

Faculty of Dentistry, The University of Hong Kong, Hong Kong 999077, China
College of Stomatology, Anhui Medical University, Hefei 230032, China
Authors to whom correspondence should be addressed.
Academic Editor: Marco Salerno
Materials 2016, 9(6), 414;
Received: 15 February 2016 / Revised: 17 May 2016 / Accepted: 23 May 2016 / Published: 25 May 2016
(This article belongs to the Section Biomaterials)
Root caries prevention has been a challenge for clinicians due to its special anatomical location, which favors the accumulation of dental plaque. Researchers are looking for anti-biofouling material to inhibit bacterial growth on exposed root surfaces. This study aimed to develop polydopamine-induced-polyethylene glycol (PEG) and to study its anti-biofouling effect against a multi-species cariogenic biofilm on the root dentine surface. Hydroxyapatite disks and human dentine blocks were divided into four groups for experiments. They received polydopamine-induced-PEG, PEG, polydopamine, or water application. Contact angle, quartz crystal microbalance, and Fourier transform infrared spectroscopy were used to study the wetting property, surface affinity, and an infrared spectrum; the results indicated that PEG was induced by polydopamine onto a hydroxyapatite disk. Salivary mucin absorption on hydroxyapatite disks with polydopamine-induced-PEG was confirmed using spectrophotometry. The growth of a multi-species cariogenic biofilm on dentine blocks with polydopamine-induced-PEG was assessed and monitored by colony-forming units, confocal laser scanning microscopy, and scanning electron microscopy. The results showed that dentine with polydopamine-induced-PEG had fewer bacteria than other groups. In conclusion, a novel polydopamine-induced-PEG coating was developed. Its anti-biofouling effect inhibited salivary mucin absorption and cariogenic biofilm formation on dentine surface and thus may be used for the prevention of root dentine caries. View Full-Text
Keywords: root caries; polydopamine; polyethylene; dentine; biofouling root caries; polydopamine; polyethylene; dentine; biofouling
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Mei, M.L.; Li, Q.-L.; Chu, C.H. Inhibition of Cariogenic Plaque Formation on Root Surface with Polydopamine-Induced-Polyethylene Glycol Coating. Materials 2016, 9, 414.

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