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Open AccessFeature PaperArticle

Collagen Type I Conduits for the Regeneration of Nerve Defects

Center for Plastic-, Hand- and Reconstructive Surgery, University Hospital Regensburg, Franz-Josef-Strauss-Allee 11, Regensburg 93053, Germany
Translational Molecular Pathology, University of Texas MD, Unit 951, 7435 Fannin Street, Houston, TX 77054, USA
Department of Orthopaedic Trauma Surgery, University Medical Center Aachen, Pauwelsstrasse 30, Aachen 52074, Germany
Author to whom correspondence should be addressed.
Academic Editor: C. Edi Tanase
Materials 2016, 9(4), 219;
Received: 24 January 2016 / Revised: 6 March 2016 / Accepted: 14 March 2016 / Published: 23 March 2016
(This article belongs to the Special Issue Regenerative Materials)
To date, reliable data to support the general use of biodegradable materials for bridging nerve defects are still scarce. We present the outcome of nerve regeneration following type I collagen conduit nerve repair in patients with large-diameter nerve gaps. Ten patients underwent nerve repair using a type I collagen nerve conduit. Patients were re-examined at a minimal follow-up of 14.0 months and a mean follow-up of 19.9 months. Regeneration of nerve tissue within the conduits was assessed by nerve conduction velocity (NCV), a static two-point discrimination (S2PD) test, and as disability of arm shoulder and hand (DASH) outcome measure scoring. Quality of life measures including patients’ perceived satisfaction and residual pain were evaluated using a visual analog scale (VAS). No implant-related complications were observed. Seven out of 10 patients reported being free of pain, and the mean VAS was 1.1. The mean DASH score was 17.0. The S2PD was below 6 mm in 40%, between 6 and 10 mm in another 40% and above 10 mm in 20% of the patients. Eight out of 10 patients were satisfied with the procedure and would undergo surgery again. Early treatment correlated with lower DASH score levels. The use of type I collagen in large-diameter gaps in young patients and early treatment presented superior functional outcomes. View Full-Text
Keywords: Type I collagen nerve conduit; biocompatibility; peripheral nerve repair Type I collagen nerve conduit; biocompatibility; peripheral nerve repair
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Klein, S.; Vykoukal, J.; Felthaus, O.; Dienstknecht, T.; Prantl, L. Collagen Type I Conduits for the Regeneration of Nerve Defects. Materials 2016, 9, 219.

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