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Open AccessArticle

Silica-Gentamicin Nanohybrids: Synthesis and Antimicrobial Action

Department of Materials Science and Engineering, School of Chemical Technology, Aalto University, 02150 Espoo, Finland
Microbiological Unit, Fish Diseases Department, Animal Health Research Institute, Dokki, 12618 Giza, Egypt
Department of Biotechnology and Chemical Technology, School of Chemical Technology, Aalto University, 02150 Espoo, Finland
Author to whom correspondence should be addressed.
Academic Editor: Mauro Pollini
Materials 2016, 9(3), 170;
Received: 12 December 2015 / Revised: 19 February 2016 / Accepted: 29 February 2016 / Published: 5 March 2016
(This article belongs to the Special Issue Advances and Applications of Nano-antimicrobial Treatments)
Orthopedic applications commonly require the administration of systemic antibiotics. Gentamicin is one of the most commonly used aminoglycosides in the treatment and prophylaxis of infections associated with orthopedic applications, but gentamicin has a short half-life. However, silica nanoparticles (SiO2 NPs) can be used as elegant carriers for antibiotics to prolong their release. Our goal is the preparation and characterization of SiO2-gentamicin nanohybrids for their potential antimicrobial administration in orthopedic applications. In vitro gentamicin release profile from the nanohybrids (gentamicin-conjugated SiO2 NPs) prepared by the base-catalyzed precipitation exhibited fast release (21.4%) during the first 24 h and further extension with 43.9% release during the five-day experiment. Antimicrobial studies of the SiO2-gentamicin nanohybrids versus native SiO2 NPs and free gentamicin were performed against Bacillus subtilis (B. subtilis), Pseudomonas fluorescens (P. fluorescens) and Escherichia coli (E. coli). SiO2-gentamicin nanohybrids were most effective against B. subtilis. SiO2 NPs play no antimicrobial role. Parallel antimicrobial studies for the filter-sterilized gentamicin were performed to assess the effect of ultraviolet (UV)-irradiation on gentamicin. In summary, the initial fast gentamicin release fits the need for high concentration of antibiotics after orthopedic surgical interventions. Moreover, the extended release justifies the promising antimicrobial administration of the nanohybrids in bone applications. View Full-Text
Keywords: silica nanoparticles; gentamicin; in vitro release; antimicrobial effect; orthopedic applications silica nanoparticles; gentamicin; in vitro release; antimicrobial effect; orthopedic applications
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Mosselhy, D.A.; Ge, Y.; Gasik, M.; Nordström, K.; Natri, O.; Hannula, S.-P. Silica-Gentamicin Nanohybrids: Synthesis and Antimicrobial Action. Materials 2016, 9, 170.

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