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Open AccessArticle

Influence of Amphibian Antimicrobial Peptides and Short Lipopeptides on Bacterial Biofilms Formed on Contact Lenses

1
Department of Inorganic Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Gdansk 80-416, Poland
2
Pharmaceutical Laboratory, Avena SJ, Osielsko 86-031, Poland
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Mauro Pollini
Materials 2016, 9(11), 873; https://doi.org/10.3390/ma9110873
Received: 25 July 2016 / Revised: 22 September 2016 / Accepted: 20 October 2016 / Published: 26 October 2016
(This article belongs to the Special Issue Advances and Applications of Nano-antimicrobial Treatments)
The widespread use of contact lenses is associated with several complications, including ocular biofilm-related infections. They are very difficult to manage with standard antimicrobial therapies, because bacterial growth in a biofilm is associated with an increased antibiotic resistance. The principal aim of this study was to evaluate the efficacy of antimicrobial peptides (AMPs) in eradication of bacterial biofilms formed on commercially available contact lenses. AMPs were synthesized according to Fmoc/tBu chemistry using the solid-phase method. Minimum inhibitory concentration (MIC) and minimum biofilm eradication concentration (MBEC) of the compounds were determined. Anti-biofilm activity of the antimicrobial peptides determined at different temperatures (25 °C and 37 °C) were compared with the effectiveness of commercially available contact lens solutions. All of the tested compounds exhibited stronger anti-biofilm properties as compared to those of the tested lens solutions. The strongest activity of AMPs was noticed against Gram-positive strains at a temperature of 25 °C. Conclusions: The results of our experiments encourage us toward further studies on AMPs and their potential application in the prophylaxis of contact lens-related eye infections. View Full-Text
Keywords: antimicrobial peptides; lipopeptides; biofilm; ocular infections; contact lenses antimicrobial peptides; lipopeptides; biofilm; ocular infections; contact lenses
MDPI and ACS Style

Maciejewska, M.; Bauer, M.; Neubauer, D.; Kamysz, W.; Dawgul, M. Influence of Amphibian Antimicrobial Peptides and Short Lipopeptides on Bacterial Biofilms Formed on Contact Lenses. Materials 2016, 9, 873.

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