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Bone Augmentation in Rabbit Tibia Using Microfixed Cobalt-Chromium Membranes with Whole Blood and Platelet-Rich Plasma

Department of Bioingenieering, Faculty of Engineering, National University of Entre Ríos, Route 11 Km.10, Oro Verde (Paraná)-Entre Ríos 3100, Argentina
CIMOFIR Research Centre, Faculty of Dentistry, University of La Frontera, Temuco 4781176, Chile
Department of Maxillofacial Surgery, Georg-August-University Hospital, Robert Koch Str. 40, Göttingen D-37075, Germany
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Georgios E. Romanos
Materials 2015, 8(8), 4843-4856;
Received: 2 May 2015 / Revised: 6 June 2015 / Accepted: 29 June 2015 / Published: 30 July 2015
(This article belongs to the Special Issue Bioceramics)
PDF [886 KB, uploaded 30 July 2015]


Background: Bone augmentation is a subject of intensive investigation in regenerative bone medicine and constitutes a clinical situation in which autogenous bone grafts or synthetic materials are used to aid new bone formation. Method: Based on a non-critical defect, Co-Cr barrier membranes were placed on six adult Fauve de Bourgogne rabbits, divided into two groups: whole blood and PRP. Three densitometric controls were performed during the experiment. The animals were euthanized at 30, 45, 60, and 110 days. The presence of newly formed bone was observed. Samples for histological studies were taken from the augmentation center. Results: External and internal bone tissue augmentation was observed in almost all cases. Significant differences between PRP- and whole blood–stimulated bone augmentation were not observed. At 60 days, bones with PRP presented higher angiogenesis, which may indicate more proliferation and cellular activity. Conclusion: PRP activates the bone regeneration process under optimized conditions by stimulation of osteoblast proliferation after six weeks, when a significant difference in cellular activity was observed. Membranes could stimulate bone augmentation at the site of placement and in the surrounding areas. View Full-Text
Keywords: bone augmentation; cobalt-chromium membranes; microscrew; platelet-rich plasma bone augmentation; cobalt-chromium membranes; microscrew; platelet-rich plasma

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Decco, O.A.; Beltrán, V.; Zuchuat, J.I.; Cura, A.C.; Lezcano, M.F.; Engelke, W. Bone Augmentation in Rabbit Tibia Using Microfixed Cobalt-Chromium Membranes with Whole Blood and Platelet-Rich Plasma. Materials 2015, 8, 4843-4856.

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