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Open AccessArticle

Evaluation of Lapatinib Powder-Entrapped Biodegradable Polymeric Microstructures Fabricated by X-Ray Lithography for a Targeted and Sustained Drug Delivery System

1
Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-799, Korea
2
Inter-university Semiconductor Research Center, Automation System Research Institute, School of Electrical Engineering and Computer Science, Seoul National University, Seoul 151-744, Korea
3
Department of Internal Medicine, Seoul National University Hospital, Seoul 110-744, Korea
4
Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University College of Medicine, Seoul 110-799, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Loo Say Chye Joachim
Materials 2015, 8(2), 519-534; https://doi.org/10.3390/ma8020519
Received: 1 December 2014 / Revised: 16 January 2015 / Accepted: 30 January 2015 / Published: 5 February 2015
(This article belongs to the Special Issue Materials for Drug Delivery)
An oral medication of a molecular targeted drug, lapatinib, is taken regularly to maintain the drug concentration within the desired therapeutic levels. To alleviate the need for such cumbersome administration schedules in several drugs, advanced drug delivery systems (DDSs), which can provide time-controlled and sustained drug release, have recently received significant attention. A biodegradable synthetic polymer, such as polycaprolactone (PCL), is usually used as a carrier material for DDSs. In this paper, lapatinib powder-entrapped, PCL microstructures were fabricated with a precise X-ray lithography-based method. In vitro experiments on HER2 positive-human gastric cancer derived NCI-N87 cells were performed to appraise the drug release characteristics of the fabricated DDSs. The in vitro results indicate that after the X-ray lithography process, the lapatinib powder is still working well and show time- and dose- dependent drug release efficiencies. The cell growth inhibition characteristics of one hundred 40-μm sized microstructures were similar to those of a 1 μM lapatinib solution for over 144 h. In conclusion, the developed lapatinib-entrapped PCL microstructures can be used in molecular targeted delivery and sustained release as effective cancer-targeted DDSs. View Full-Text
Keywords: drug delivery system (DDS); molecular targeted therapy; lapatinib; gastric cancer; sustained drug release; biodegradable polymer; polycaprolactone (PCL) drug delivery system (DDS); molecular targeted therapy; lapatinib; gastric cancer; sustained drug release; biodegradable polymer; polycaprolactone (PCL)
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Jeong, E.-G.; Yoo, H.J.; Song, B.; Kim, H.-P.; Han, S.-W.; Kim, T.-Y.; Cho, D.-I.D. Evaluation of Lapatinib Powder-Entrapped Biodegradable Polymeric Microstructures Fabricated by X-Ray Lithography for a Targeted and Sustained Drug Delivery System. Materials 2015, 8, 519-534.

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