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A Photolithographic Approach to Polymeric Microneedles Array Fabrication

Institute for Microelectronics and Microsystems, National Council of Research, Via Pietro Castellino 111, Napoli 80131, Italy
IMAST Scarl, Piazza Bovio 22, Naples 80133, Italy
Department of Physics, University of Napoli “Federico II”, Via Cinthia, Napoli 80100, Italy
STMicroelectronics, via Remo De Feo 1, Arzano, Napoli 80022, Italy
Author to whom correspondence should be addressed.
Academic Editor: Juergen Stampfl
Materials 2015, 8(12), 8661-8673;
Received: 2 October 2015 / Revised: 2 December 2015 / Accepted: 3 December 2015 / Published: 11 December 2015
(This article belongs to the Section Manufacturing Processes and Systems)
In this work, two procedures for fabrication of polymeric microneedles based on direct photolithography, without any etching or molding process, are reported. Polyethylene glycol (average molecular weight 250 Da), casted into a silicone vessel and exposed to ultraviolet light (365 nm) through a mask, cross-links when added by a commercial photocatalyzer. By changing the position of the microneedles support with respect to the vessel, different shapes and lengths can be achieved. Microneedles from a hundred microns up to two millimeters have been obtained just tuning the radiation dose, by changing the exposure time (5–15 s) and/or the power density (9–18 mW/cm2) during photolithography. Different microneedle shapes, such as cylindrical, conic or lancet-like, for specific applications such as micro-indentation or drug delivery, are demonstrated. View Full-Text
Keywords: microneedles; photolithography; polymers microneedles; photolithography; polymers
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MDPI and ACS Style

Dardano, P.; Caliò, A.; Di Palma, V.; Bevilacqua, M.F.; Di Matteo, A.; De Stefano, L. A Photolithographic Approach to Polymeric Microneedles Array Fabrication. Materials 2015, 8, 8661-8673.

AMA Style

Dardano P, Caliò A, Di Palma V, Bevilacqua MF, Di Matteo A, De Stefano L. A Photolithographic Approach to Polymeric Microneedles Array Fabrication. Materials. 2015; 8(12):8661-8673.

Chicago/Turabian Style

Dardano, Principia, Alessandro Caliò, Vincenza Di Palma, Maria F. Bevilacqua, Andrea Di Matteo, and Luca De Stefano. 2015. "A Photolithographic Approach to Polymeric Microneedles Array Fabrication" Materials 8, no. 12: 8661-8673.

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