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Structural Consideration in Designing Organotin Polyethers to Arrest the Growth of Breast Cancer Cells In Vitro

1
Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431, USA
2
Florida Center for Environmental Studies, Palm Beach Gardens, FL 33410, USA
3
Department of Biology, University of Texas Arlington, Arlington, TX 76019, USA
4
Department of Biological Sciences, University of North Texas, Denton, TX 76203, USA
5
Department of Biology, Boston University, Boston, MA 02215, USA
*
Author to whom correspondence should be addressed.
Materials 2011, 4(4), 801-815; https://doi.org/10.3390/ma4040801
Received: 11 February 2011 / Revised: 4 April 2011 / Accepted: 8 April 2011 / Published: 15 April 2011
(This article belongs to the Special Issue Metal-Containing Polymers)
The ability to inhibit cancer is inherent in organotin materials yet the structural relationships that regulate/direct this activity remains unknown. We measured antitumor activity using a matched pair of cell lines MDA-MB-231 cells that are estrogen-independent, estrogen receptor negative and MCF-7 cells, a cell line that is estrogen receptor (ER) positive. Those polyethers that contained a O-phenyl unit were able to significantly inhibit the non-estrogen sensitive cell line but were much less effective against the estrogen sensitive cell line; that is, the human breast cancer cell line MDA-MB-231 showed better test results for polymers derived from diols containing the O-phenyl moiety than the breast cancer cell line MCF-7, a well-characterized estrogen receptor positive control cell line. Those polyethers that did not contain the O-phenyl unit inhibited both cell lines approximately the same. The differential activity of the O-phenyl-containing polyethers is likely due to the estrogen-sensitive cells combining with some of the organotin polyethers minimizing their ability to inhibit cell growth. View Full-Text
Keywords: tin-containing polymers; cancer; breast cancer; organotin compounds; organotin polyethers; estrogen receptor positive breast cancer; estrogen-independent breast cancer tin-containing polymers; cancer; breast cancer; organotin compounds; organotin polyethers; estrogen receptor positive breast cancer; estrogen-independent breast cancer
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Carraher Jr., C.E.; Roner, M.R.; Shahi, K.; Barot, G. Structural Consideration in Designing Organotin Polyethers to Arrest the Growth of Breast Cancer Cells In Vitro. Materials 2011, 4, 801-815.

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