Next Article in Journal
Electrochemical Light-Emitting Gel
Next Article in Special Issue
Characterization of Biomaterials by Soft X-Ray Spectromicroscopy
Previous Article in Journal
Properties and Clinical Application of Three Types of Dental Glass-Ceramics and Ceramics for CAD-CAM Technologies
Previous Article in Special Issue
Polymeric Microspheres for Medical Applications
Open AccessArticle

Electrospun Biocomposite Polycaprolactone/Collagen Tubes as Scaffolds for Neural Stem Cell Differentiation

1
Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, Ontario, K1H 8L6, Canada
2
Department of Clinical and Experimental Medicine, Linköping University, 581 85 Linköping, Sweden
3
Ottawa Hospital Research Institute, 725 Parkdale Avenue, Ottawa, Ontario, K1Y 4E9, Canada
4
Department of Chemical and Biological Engineering, University of Ottawa, 161 Louis-Pasteur, Ottawa, Ontario, K1N 6N5, Canada
*
Author to whom correspondence should be addressed.
Materials 2010, 3(6), 3714-3728; https://doi.org/10.3390/ma3063714
Received: 4 May 2010 / Accepted: 17 June 2010 / Published: 19 June 2010
(This article belongs to the Special Issue Advances in Biomaterials)
Studies using cellular therapies, scaffolds, and tubular structured implants have been carried out with the goal to restore functional recovery after spinal cord injury (SCI). None of these therapeutic strategies, by themselves, have been shown to be sufficient to achieve complete restoration of function. To reverse the devastating effects of SCI, an interdisciplinary approach that combines materials science and engineering, stem cell biology, and neurosurgery is being carried out. We are currently investigating a scaffold that has the ability to deliver growth factors for the proliferation and differentiation of endogenous stem cells. Neural stem cells (NSCs) derived from mice are being used to assess the efficacy of the release of growth factors from the scaffold in vitro. The fabrication of the tubular implant allows a porous scaffold to be formed, which aids in the release of growth factors added to the scaffold. View Full-Text
Keywords: neurospheres; nerve tissue engineering; electrospun nanofibers; differentiation neurospheres; nerve tissue engineering; electrospun nanofibers; differentiation
Show Figures

Graphical abstract

MDPI and ACS Style

Hackett, J.M.; Dang, T.T.; Tsai, E.C.; Cao, X. Electrospun Biocomposite Polycaprolactone/Collagen Tubes as Scaffolds for Neural Stem Cell Differentiation. Materials 2010, 3, 3714-3728. https://doi.org/10.3390/ma3063714

AMA Style

Hackett JM, Dang TT, Tsai EC, Cao X. Electrospun Biocomposite Polycaprolactone/Collagen Tubes as Scaffolds for Neural Stem Cell Differentiation. Materials. 2010; 3(6):3714-3728. https://doi.org/10.3390/ma3063714

Chicago/Turabian Style

Hackett, Joanne M.; Dang, ThucNhi T.; Tsai, Eve C.; Cao, Xudong. 2010. "Electrospun Biocomposite Polycaprolactone/Collagen Tubes as Scaffolds for Neural Stem Cell Differentiation" Materials 3, no. 6: 3714-3728. https://doi.org/10.3390/ma3063714

Find Other Styles

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Search more from Scilit
 
Search
Back to TopTop