Next Article in Journal
Electrochemical Light-Emitting Gel
Next Article in Special Issue
Characterization of Biomaterials by Soft X-Ray Spectromicroscopy
Previous Article in Journal
Properties and Clinical Application of Three Types of Dental Glass-Ceramics and Ceramics for CAD-CAM Technologies
Previous Article in Special Issue
Polymeric Microspheres for Medical Applications
Article Menu

Export Article

Open AccessArticle
Materials 2010, 3(6), 3714-3728;

Electrospun Biocomposite Polycaprolactone/Collagen Tubes as Scaffolds for Neural Stem Cell Differentiation

Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, Ontario, K1H 8L6, Canada
Department of Clinical and Experimental Medicine, Linköping University, 581 85 Linköping, Sweden
Ottawa Hospital Research Institute, 725 Parkdale Avenue, Ottawa, Ontario, K1Y 4E9, Canada
Department of Chemical and Biological Engineering, University of Ottawa, 161 Louis-Pasteur, Ottawa, Ontario, K1N 6N5, Canada
Author to whom correspondence should be addressed.
Received: 4 May 2010 / Accepted: 17 June 2010 / Published: 19 June 2010
(This article belongs to the Special Issue Advances in Biomaterials)
Full-Text   |   PDF [462 KB, uploaded 19 June 2010]   |  


Studies using cellular therapies, scaffolds, and tubular structured implants have been carried out with the goal to restore functional recovery after spinal cord injury (SCI). None of these therapeutic strategies, by themselves, have been shown to be sufficient to achieve complete restoration of function. To reverse the devastating effects of SCI, an interdisciplinary approach that combines materials science and engineering, stem cell biology, and neurosurgery is being carried out. We are currently investigating a scaffold that has the ability to deliver growth factors for the proliferation and differentiation of endogenous stem cells. Neural stem cells (NSCs) derived from mice are being used to assess the efficacy of the release of growth factors from the scaffold in vitro. The fabrication of the tubular implant allows a porous scaffold to be formed, which aids in the release of growth factors added to the scaffold. View Full-Text
Keywords: neurospheres; nerve tissue engineering; electrospun nanofibers; differentiation neurospheres; nerve tissue engineering; electrospun nanofibers; differentiation

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Hackett, J.M.; Dang, T.T.; Tsai, E.C.; Cao, X. Electrospun Biocomposite Polycaprolactone/Collagen Tubes as Scaffolds for Neural Stem Cell Differentiation. Materials 2010, 3, 3714-3728.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top