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Collagen-Based Biomaterials for Tissue Engineering Applications

Laboratoire d’Organogénèse Expérimentale (LOEX), Centre de recherche FRSQ du CHA universitaire de Québec, Hôpital du Saint-Sacrement, Québec, QC, G1S 4L8 Canada
Département de chirurgie, Faculté de médecine, Université Laval, Québec, QC, G1V 0A6 Canada
Author to whom correspondence should be addressed.
Materials 2010, 3(3), 1863-1887;
Received: 2 February 2010 / Revised: 9 March 2010 / Accepted: 11 March 2010 / Published: 16 March 2010
(This article belongs to the Special Issue Advances in Biomaterials)
Collagen is the most widely distributed class of proteins in the human body. The use of collagen-based biomaterials in the field of tissue engineering applications has been intensively growing over the past decades. Multiple cross-linking methods were investigated and different combinations with other biopolymers were explored in order to improve tissue function. Collagen possesses a major advantage in being biodegradable, biocompatible, easily available and highly versatile. However, since collagen is a protein, it remains difficult to sterilize without alterations to its structure. This review presents a comprehensive overview of the various applications of collagen-based biomaterials developed for tissue engineering, aimed at providing a functional material for use in regenerative medicine from the laboratory bench to the patient bedside. View Full-Text
Keywords: collagen; biomaterial; soft tissue collagen; biomaterial; soft tissue
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Parenteau-Bareil, R.; Gauvin, R.; Berthod, F. Collagen-Based Biomaterials for Tissue Engineering Applications. Materials 2010, 3, 1863-1887.

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