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Structures and Dissolution Behaviors of Quaternary CaO-SrO-P2O5-TiO2 Glasses

National Institute of Advanced Industrial Science and Technology (AIST), 2266-98 Anagahora, Shimoshidami, Moriyama-ku, Nagoya 463-8560, Japan
Division of Materials and Manufacturing Science, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan
Division of Advanced Ceramics, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555, Japan
Author to whom correspondence should be addressed.
Academic Editor: Aivaras Kareiva
Materials 2021, 14(7), 1736;
Received: 24 February 2021 / Revised: 18 March 2021 / Accepted: 20 March 2021 / Published: 1 April 2021
(This article belongs to the Special Issue Bioceramics and Related Hybrid Materials for Tissue Reconstruction)
Calcium phosphate glasses have a high potential for use as biomaterials because their composition is similar to that of the mineral phase of bone. Phosphate glasses can dissolve completely in aqueous solution and can contain various elements owing to their acidity. Thus, the glass can be a candidate for therapeutic ion carriers. Recently, we focused on the effect of strontium ions for bone formation, which exhibited dual effects of stimulating bone formation and inhibiting bone resorption. However, large amounts of strontium ions may induce a cytotoxic effect, and there is a need to control their releasing amount. This work reports fundamental data for designing quaternary CaO-SrO-P2O5-TiO2 glasses with pyro- and meta-phosphate compositions to control strontium ion-releasing behavior. The glasses were prepared by substituting CaO by SrO using the melt-quenching method. The SrO/CaO mixed composition exhibited a mixed cation effect on the glassification degree and ion-releasing behavior, which showed non-linear properties with mixed cation compositions of the glasses. Sr2+ ions have smaller field strength than Ca2+ ions, and the glass network structure may be weakened by the substitution of CaO by SrO. However, glassification degree and chemical durability of pyro- and meta-phosphate glasses increased with substituted all CaO by SrO. This is because titanium groups in the glasses are closely related to their glass network structure by SrO substitution. The P-O-Ti bonds in pyrophosphate glass series and TiO4 tetrahedra in metaphosphate glass series increased with substitution by SrO. The titanium groups in the glasses were crosslink and/or coordinate phosphate groups to improve glassification degree and chemical durability. Sr2+ ion releasing amount of pyrophosphate glasses with >83% SrO substitution was larger than 0.1 mM at day seven, an amount that reported enhanced bone formation by stimulation of osteogenic markers. View Full-Text
Keywords: bioactive glass; phosphate glass; structure; dissolution behavior; strontium bioactive glass; phosphate glass; structure; dissolution behavior; strontium
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MDPI and ACS Style

Lee, S.; Nagata, F.; Kato, K.; Nakano, T.; Kasuga, T. Structures and Dissolution Behaviors of Quaternary CaO-SrO-P2O5-TiO2 Glasses. Materials 2021, 14, 1736.

AMA Style

Lee S, Nagata F, Kato K, Nakano T, Kasuga T. Structures and Dissolution Behaviors of Quaternary CaO-SrO-P2O5-TiO2 Glasses. Materials. 2021; 14(7):1736.

Chicago/Turabian Style

Lee, Sungho, Fukue Nagata, Katsuya Kato, Takayoshi Nakano, and Toshihiro Kasuga. 2021. "Structures and Dissolution Behaviors of Quaternary CaO-SrO-P2O5-TiO2 Glasses" Materials 14, no. 7: 1736.

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