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Degradation and Characterisation of Electrospun Polycaprolactone (PCL) and Poly(lactic-co-glycolic acid) (PLGA) Scaffolds for Vascular Tissue Engineering
Article

Fabrication and Characterization of PCL/PLGA Coaxial and Bilayer Fibrous Scaffolds for Tissue Engineering

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Department of Biomedical and Electronics Engineering, School of Engineering, University of Bradford, Bradford BD7 1DP, UK
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State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute at Sichuan University, Chengdu 610065, China
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Advanced Polymer Materials Research Center, Sichuan University, Shishi 362700, China
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Chongqing Key Laboratory of Oral Disease and Biomedical Sciences and Chongqing Municipal Key Laboratory of Oral Biomedical Engineering, Higher Education and Stomatological Hospital, Chongqing Medical University, Chongqing 401174, China
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School of Pharmacy and Medical Sciences, Faculty of Life Sciences, University of Bradford, Bradford BD7 1DP, UK
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Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad 91779-4897, Iran
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Interdisciplinary Research Centre in Polymer Science and Technology (Polymer IRC), University of Bradford, Bradford BD7 1DP, UK
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Author to whom correspondence should be addressed.
Academic Editors: Ana Ferreira-Duarte and Piergiorgio Gentile
Materials 2021, 14(21), 6295; https://doi.org/10.3390/ma14216295
Received: 9 August 2021 / Revised: 25 September 2021 / Accepted: 11 October 2021 / Published: 22 October 2021
(This article belongs to the Special Issue Biomaterials and Bio-Fabrication of Scaffolds for Tissue Engineering)
Electrospinning is an innovative new fibre technology that aims to design and fabricate membranes suitable for a wide range of tissue engineering (TE) applications including vascular grafts, which is the main objective of this research work. This study dealt with fabricating and characterising bilayer structures comprised of an electrospun sheet made of polycaprolactone (PCL, inner layer) and an outer layer made of poly lactic-co-glycolic acid (PLGA) and a coaxial porous scaffold with a micrometre fibre structure was successfully produced. The membranes’ propriety for intended biomedical applications was assessed by evaluating their morphological structure/physical properties and structural integrity when they underwent the degradation process. A scanning electron microscope (SEM) was used to assess changes in the electrospun scaffolds’ structural morphology such as in their fibre diameter, pore size (μm) and the porosity of the scaffold surface which was measured with Image J software. During the 12-week degradation process at room temperature, most of the scaffolds showed a similar trend in their degradation rate except the 60 min scaffolds. The coaxial scaffold had significantly less mass loss than the bilayer PCL/PLGA scaffold with 1.348% and 18.3%, respectively. The mechanical properties of the fibrous membranes were measured and the coaxial scaffolds showed greater tensile strength and elongation at break (%) compared to the bilayer scaffolds. According to the results obtained in this study, it can be concluded that a scaffold made with a coaxial needle is more suitable for tissue engineering applications due to the improved quality and functionality of the resulting polymeric membrane compared to the basic electrospinning process. However, whilst fabricating a vascular graft is the main aim of this research work, the biological data will not present in this paper. View Full-Text
Keywords: electrospinning; coaxial; bilayer; polycaprolactone (PCL); poly lactic-co-glycolic acid (PLGA); contact angle; mechanical properties; degradation electrospinning; coaxial; bilayer; polycaprolactone (PCL); poly lactic-co-glycolic acid (PLGA); contact angle; mechanical properties; degradation
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MDPI and ACS Style

Bazgir, M.; Zhang, W.; Zhang, X.; Elies, J.; Saeinasab, M.; Coates, P.; Youseffi, M.; Sefat, F. Fabrication and Characterization of PCL/PLGA Coaxial and Bilayer Fibrous Scaffolds for Tissue Engineering. Materials 2021, 14, 6295. https://doi.org/10.3390/ma14216295

AMA Style

Bazgir M, Zhang W, Zhang X, Elies J, Saeinasab M, Coates P, Youseffi M, Sefat F. Fabrication and Characterization of PCL/PLGA Coaxial and Bilayer Fibrous Scaffolds for Tissue Engineering. Materials. 2021; 14(21):6295. https://doi.org/10.3390/ma14216295

Chicago/Turabian Style

Bazgir, Morteza, Wei Zhang, Ximu Zhang, Jacobo Elies, Morvarid Saeinasab, Phil Coates, Mansour Youseffi, and Farshid Sefat. 2021. "Fabrication and Characterization of PCL/PLGA Coaxial and Bilayer Fibrous Scaffolds for Tissue Engineering" Materials 14, no. 21: 6295. https://doi.org/10.3390/ma14216295

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