Next Article in Journal
Enhancing Strain Capacity by the Introduction of Pearlite in Bainite and Polygonal Ferrite Dual-Phase Pipeline Steel
Previous Article in Journal
Preserving the Cellular Tissue Structure of Maize Pith Though Dry Fractionation Processes: A Key Point to Use as Insulating Agro-Materials
Article

Pentamethinium Salts Nanocomposite for Electrochemical Detection of Heparin

1
Department of Analytical Chemistry, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic
2
BIOCEV, First Faculty of Medicine, Charles University, Průmyslová 595, 252 50 Vestec, Czech Republic
3
Department of Paediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University and General University Hospital, Kateřinská 1660/32, 121 08 Prague 2, Czech Republic
*
Author to whom correspondence should be addressed.
Academic Editor: Paulo José Gomes Coutinho
Materials 2021, 14(18), 5357; https://doi.org/10.3390/ma14185357
Received: 12 August 2021 / Revised: 3 September 2021 / Accepted: 14 September 2021 / Published: 17 September 2021
This study presents a simple route to heparin detection and develops a voltammetric approach using supramolecular principles and nanomaterials. Nanocomposites, including gold nanoparticles (AuNPs) and γ-substituted pentamethinium salts (PMS) deposited on a glass carbon (GC) electrode surface (GC/AuNPs/PMS) and covered by a plasticized poly(vinyl chloride) (PVC) membrane, are proposed for heparin detection. The conductivity of the nonconducting PVC-plasticized membrane is guaranteed by AuNPs, and the selectivity is provided by the interaction between γ-substituted PMS and anionic analytes. In order to extend the linear range, it is necessary to apply a solvent compatible with PVC-plasticized membrane, namely tetrahydrofuran. The proposed voltammetric sensor showed a concentration dependence from 1.72 up to 45.02 IU mL−1 heparin and was used for heparin detection in saline and biological samples with recovery of 95.1–100.9%. View Full-Text
Keywords: gold nanoparticles; γ-substituted pentamethinium salts; nanocomposite; voltammetric sensor; heparin gold nanoparticles; γ-substituted pentamethinium salts; nanocomposite; voltammetric sensor; heparin
Show Figures

Graphical abstract

MDPI and ACS Style

Shishkanova, T.V.; Bříza, T.; Řezanka, P.; Kejík, Z.; Jakubek, M. Pentamethinium Salts Nanocomposite for Electrochemical Detection of Heparin. Materials 2021, 14, 5357. https://doi.org/10.3390/ma14185357

AMA Style

Shishkanova TV, Bříza T, Řezanka P, Kejík Z, Jakubek M. Pentamethinium Salts Nanocomposite for Electrochemical Detection of Heparin. Materials. 2021; 14(18):5357. https://doi.org/10.3390/ma14185357

Chicago/Turabian Style

Shishkanova, Tatiana V., Tomáš Bříza, Pavel Řezanka, Zdeněk Kejík, and Milan Jakubek. 2021. "Pentamethinium Salts Nanocomposite for Electrochemical Detection of Heparin" Materials 14, no. 18: 5357. https://doi.org/10.3390/ma14185357

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop