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Article

Development of Biodegradable Polymer Blends Based on Chitosan and Polylactide and Study of Their Properties

1
Chemistry Department, National Research Lobachevsky State University of Nizhny Novgorod, 23 Gagarin Ave, 603022 Nizhny Novgorod, Russia
2
G. A. Razuvaev Institute of Organometallic Chemistry, Russian Academy of Sciences, 49 Tropinina St., 603950 Nizhny Novgorod, Russia
*
Author to whom correspondence should be addressed.
Academic Editor: Yury A. Skorik
Materials 2021, 14(17), 4900; https://doi.org/10.3390/ma14174900
Received: 22 July 2021 / Revised: 24 August 2021 / Accepted: 25 August 2021 / Published: 28 August 2021
(This article belongs to the Special Issue Advances in Polysaccharide Biomaterials—Volume II)
Composite materials of various compositions based on chitosan and polylactide were obtained in the form of films or porous bulk samples. Preliminarily, poly-d,l-lactide was synthesized by ring-opening polymerization of lactide in the presence of Ti(OiPr)4. Polylactide obtained at components molar ratio [lactide]:[Ti(OiPr)4] = 3:1 had the best molecular weight characteristics at a high product yield. Film composition with the weight ratio chitosan-polylactide 50:50 wt. % was characterized by high mechanical properties. The value of the tensile strength of the film was 72 MPa with a deformation of 10% and an elastic modulus of 40 GPa, which is higher than the tensile strength of native chitosan by ~three times. The observed effect is a consequence of the fact that the chitosan-polylactide composite has an amorphous structure in contrast to the native chitosan, which is proved by X-ray phase analysis. An increase in the elastic modulus of the composite in the range of 20–60 °C in contrast to polylactide was found by dynamic mechanical analysis. The observed effect is apparently caused by the formation of hydrogen bonds between functional groups of chitosan and polylactide which is possible through an increase in polylactide segments mobility when its glass transition temperature is reached. The composite material is biocompatible and characterized by high cellular adhesion of fibroblasts (line hTERT BJ-5ta). Their growth on the composite surface was 2.4 times more active than on native chitosan. Bulk porous samples of the composition with the weight ratio chitosan-polylactide 50:50 wt. % were synthesized by original method in ammonium bicarbonate presence. Samples were characterized by a porosity of 82.4% and an average pore size of 100 microns. The biodegradability of such material and absence of inflammatory processes were proven in vivo by the blood parameters of experimental animals. Thus, materials with the weight ratio chitosan-polylactide 50:50 wt. % are promising for potential use in regenerative medicine. View Full-Text
Keywords: mixed composition; chitosan; polylactide; titanium isopropoxide; biocompatibility; mechanical properties; porosity mixed composition; chitosan; polylactide; titanium isopropoxide; biocompatibility; mechanical properties; porosity
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MDPI and ACS Style

Lednev, I.; Salomatina, E.; Ilyina, S.; Zaitsev, S.; Kovylin, R.; Smirnova, L. Development of Biodegradable Polymer Blends Based on Chitosan and Polylactide and Study of Their Properties. Materials 2021, 14, 4900. https://doi.org/10.3390/ma14174900

AMA Style

Lednev I, Salomatina E, Ilyina S, Zaitsev S, Kovylin R, Smirnova L. Development of Biodegradable Polymer Blends Based on Chitosan and Polylactide and Study of Their Properties. Materials. 2021; 14(17):4900. https://doi.org/10.3390/ma14174900

Chicago/Turabian Style

Lednev, Ivan, Evgeniia Salomatina, Svetlana Ilyina, Sergey Zaitsev, Roman Kovylin, and Larisa Smirnova. 2021. "Development of Biodegradable Polymer Blends Based on Chitosan and Polylactide and Study of Their Properties" Materials 14, no. 17: 4900. https://doi.org/10.3390/ma14174900

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