Next Article in Journal
Polyelectrolyte Multilayers: An Overview on Fabrication, Properties, and Biomedical and Environmental Applications
Next Article in Special Issue
Surface Adsorption of the Cancer Biomarker Lysophosphatidic Acid in Serum Studied by Acoustic Wave Biosensor
Previous Article in Journal
Does Simulated Porcelain Firing Influence Corrosion Properties of Casted and Sintered CoCr Alloys?
Previous Article in Special Issue
The Potential Use of a Thin Film Gold Electrode Modified with Laccases for the Electrochemical Detection of Pyrethroid Metabolite 3-Phenoxybenzaldehyde

Advanced Optogenetic-Based Biosensing and Related Biomaterials

International Centre of Biodynamics, 1B Intrarea Portocalelor, 060101 Bucharest, Romania
Molecular Biology Center, Institute for Interdisciplinary Research in Bio-Nano-Sciences, Babes-Bolyai-University, 400084 Cluj-Napoca, Romania
Institute of Biology Bucharest, Romanian Academy, 296 Splaiul Independentei, 060031 Bucharest, Romania
Authors to whom correspondence should be addressed.
Academic Editor: Daniela Iannazzo
Materials 2021, 14(15), 4151;
Received: 18 June 2021 / Revised: 12 July 2021 / Accepted: 20 July 2021 / Published: 26 July 2021
(This article belongs to the Special Issue Advanced Designs of Materials, Devices and Techniques for Biosensing)
The ability to stimulate mammalian cells with light, brought along by optogenetic control, has significantly broadened our understanding of electrically excitable tissues. Backed by advanced (bio)materials, it has recently paved the way towards novel biosensing concepts supporting bio-analytics applications transversal to the main biomedical stream. The advancements concerning enabling biomaterials and related novel biosensing concepts involving optogenetics are reviewed with particular focus on the use of engineered cells for cell-based sensing platforms and the available toolbox (from mere actuators and reporters to novel multifunctional opto-chemogenetic tools) for optogenetic-enabled real-time cellular diagnostics and biosensor development. The key advantages of these modified cell-based biosensors concern both significantly faster (minutes instead of hours) and higher sensitivity detection of low concentrations of bioactive/toxic analytes (below the threshold concentrations in classical cellular sensors) as well as improved standardization as warranted by unified analytic platforms. These novel multimodal functional electro-optical label-free assays are reviewed among the key elements for optogenetic-based biosensing standardization. This focused review is a potential guide for materials researchers interested in biosensing based on light-responsive biomaterials and related analytic tools. View Full-Text
Keywords: optogenetic (light-responsive) biomaterials; cell-based biosensors; time-lapse multiparametric assays; optogenetic control; cell dynamics optogenetic (light-responsive) biomaterials; cell-based biosensors; time-lapse multiparametric assays; optogenetic control; cell dynamics
Show Figures

Graphical abstract

MDPI and ACS Style

Gheorghiu, M.; Polonschii, C.; Popescu, O.; Gheorghiu, E. Advanced Optogenetic-Based Biosensing and Related Biomaterials. Materials 2021, 14, 4151.

AMA Style

Gheorghiu M, Polonschii C, Popescu O, Gheorghiu E. Advanced Optogenetic-Based Biosensing and Related Biomaterials. Materials. 2021; 14(15):4151.

Chicago/Turabian Style

Gheorghiu, Mihaela, Cristina Polonschii, Octavian Popescu, and Eugen Gheorghiu. 2021. "Advanced Optogenetic-Based Biosensing and Related Biomaterials" Materials 14, no. 15: 4151.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop