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Open AccessArticle

The Influence of Different Classes of Amino Acids on Calcium Phosphates Seeded Growth

1
Laboratory for Biocolloids and Surface Chemistry, Division of Physical Chemistry, Ruđer Bošković Institute, Bijenička Cesta 54, 10000 Zagreb, Croatia
2
Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev Trg 19, 10000 Zagreb, Croatia
3
Laboratory for Physical Chemistry of Aquatic Systems, Division for Marine and Environmental Research, Ruđer Bošković Institute, Bijenička Cesta 54, 10000 Zagreb, Croatia
4
Laboratory for Precipitation Processes, Division of Materials Chemistry, Ruđer Bošković Institute, Bijenička Cesta 54, 10000 Zagreb, Croatia
5
Institute of Physics, Bijenička Cesta 46, 10000 Zagreb, Croatia
6
Center for Marine Research, Ruđer Bošković Institute, Giordano Paliaga 5, 52210 Rovinj, Croatia
*
Author to whom correspondence should be addressed.
Materials 2020, 13(21), 4798; https://doi.org/10.3390/ma13214798
Received: 29 September 2020 / Revised: 22 October 2020 / Accepted: 22 October 2020 / Published: 27 October 2020
(This article belongs to the Special Issue Biomimetic Organic–Inorganic Composites)
Amino acids (AAs) attract attention for elucidating the role of proteins in biomineralization and the preparation of functionalized biomaterials. The influence that AAs exert on calcium phosphate (CaP) mineralization is still not completely understood, as contradictory results have been reported. In this paper, the influence of the addition of different classes of AAs, charged (L-aspartic acid, Asp; L-lysine, Lys), polar (L-asparagine, Asn; L-serine, Ser; L-tyrosine, Tyr), and non-polar (L-phenylalanine, Phe), on CaP growth in the presence of octacalcium phosphate (OCP) and calcium hydrogenphosphate dihydrate (DCPD) seeds was investigated. In control systems (without AAs), a calcium-deficient apatite (CaDHA) layer was formed on the surface of OCP, while a mixture of CaDHA and OCP in the form of spherical aggregates was formed on the surface of DCPD crystals. Charged and non-polar promoted, while polar AAs inhibited CaDHA formation on the OCP seeds. In the case of DCPD, Lys, Asp, and Phe promoted CaP formation, while the influence of other AAs was negligible. The most efficient promotor of precipitation in both cases was non-polar Phe. No significant influence of AAs on the composition and morphology of precipitates was observed. The obtained results are of interest for understanding biomineralization processes and additive controlled material synthesis. View Full-Text
Keywords: octacalcium phosphate; dicalcium hydrogenphosphate dihydrate; amino acids; biomineralization; seeded growth octacalcium phosphate; dicalcium hydrogenphosphate dihydrate; amino acids; biomineralization; seeded growth
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MDPI and ACS Style

Mihelj Josipović, T.; Kovačević, M.; Mateša, S.; Kostešić, M.; Matijaković, N.; Radatović, B.; Lyons, D.M.; Kralj, D.; Dutour Sikirić, M. The Influence of Different Classes of Amino Acids on Calcium Phosphates Seeded Growth. Materials 2020, 13, 4798. https://doi.org/10.3390/ma13214798

AMA Style

Mihelj Josipović T, Kovačević M, Mateša S, Kostešić M, Matijaković N, Radatović B, Lyons DM, Kralj D, Dutour Sikirić M. The Influence of Different Classes of Amino Acids on Calcium Phosphates Seeded Growth. Materials. 2020; 13(21):4798. https://doi.org/10.3390/ma13214798

Chicago/Turabian Style

Mihelj Josipović, Tea; Kovačević, Monika; Mateša, Sarah; Kostešić, Marina; Matijaković, Nives; Radatović, Borna; Lyons, Daniel M.; Kralj, Damir; Dutour Sikirić, Maja. 2020. "The Influence of Different Classes of Amino Acids on Calcium Phosphates Seeded Growth" Materials 13, no. 21: 4798. https://doi.org/10.3390/ma13214798

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