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Article

Electrospun PCL Fiber Mats Incorporating Multi-Targeted B and Co Co-Doped Bioactive Glass Nanoparticles for Angiogenesis

1
Centre for Functional and Surface Functionalized Glass, TnU AD, 911 01 Trenčín, Slovakia
2
Institute of Biomaterials, University of Erlangen-Nuremberg, 91058 Erlangen, Germany
3
Joint Glass Centre of the IIC SAS, TnU AD and FChFT STU, Studentska 2, 911 50 Trenčín, Slovakia
*
Authors to whom correspondence should be addressed.
Materials 2020, 13(18), 4010; https://doi.org/10.3390/ma13184010
Received: 26 July 2020 / Revised: 25 August 2020 / Accepted: 1 September 2020 / Published: 10 September 2020
(This article belongs to the Special Issue Spotlight on Bioactive Glasses 2020)
Vascularization is necessary in tissue engineering to keep adequate blood supply in order to maintain the survival and growth of new tissue. The synergy of biologically active ions with multi-target activity may lead to superior angiogenesis promotion in comparison to single-target approaches but it has been rarely investigated. In this study, polycaprolactone (PCL) fiber mats embedded with B and Co co-doped bioactive glass nanoparticles (BCo.BGNs) were fabricated as a tissue regeneration scaffold designed for promoting angiogenesis. BCo.NBGs were successfully prepared with well-defined spherical shape using a sol-gel method. The PCL fiber mats embedding co-doped bioactive glass nanoparticles were fabricated by electrospinning using benign solvents. The Young’s moduli of the nanoparticle containing PCL fiber mats were similar to those of the neat fiber mats and suitable for scaffolds utilized in soft tissue repair approaches. The mats also showed non-cytotoxicity to ST-2 cells. PCL fiber mats containing BCo.BGNs with a relatively high content of B and Co promoted the secretion of vascular endothelial growth factor to a greater extent than PCL fiber mats with a relatively low B and Co contents, which demonstrates the potential of dual ion release (B and Co) from bioactive glasses to enhance angiogenesis in soft tissue engineering. View Full-Text
Keywords: electrospinning; bioactive glasses; sol-gel method; angiogenesis; tissue regeneration electrospinning; bioactive glasses; sol-gel method; angiogenesis; tissue regeneration
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MDPI and ACS Style

Chen, S.; Galusková, D.; Kaňková, H.; Zheng, K.; Michálek, M.; Liverani, L.; Galusek, D.; Boccaccini, A.R. Electrospun PCL Fiber Mats Incorporating Multi-Targeted B and Co Co-Doped Bioactive Glass Nanoparticles for Angiogenesis. Materials 2020, 13, 4010. https://doi.org/10.3390/ma13184010

AMA Style

Chen S, Galusková D, Kaňková H, Zheng K, Michálek M, Liverani L, Galusek D, Boccaccini AR. Electrospun PCL Fiber Mats Incorporating Multi-Targeted B and Co Co-Doped Bioactive Glass Nanoparticles for Angiogenesis. Materials. 2020; 13(18):4010. https://doi.org/10.3390/ma13184010

Chicago/Turabian Style

Chen, Si, Dagmar Galusková, Hana Kaňková, Kai Zheng, Martin Michálek, Liliana Liverani, Dušan Galusek, and Aldo R. Boccaccini 2020. "Electrospun PCL Fiber Mats Incorporating Multi-Targeted B and Co Co-Doped Bioactive Glass Nanoparticles for Angiogenesis" Materials 13, no. 18: 4010. https://doi.org/10.3390/ma13184010

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