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Open AccessArticle

Effects of UV Treatment on Ceria-Stabilized Zirconia/Alumina Nanocomposite (NANOZR)

Department of Removable Prosthodontics and Occlusion, Osaka Dental University, 8-1 Kuzuha-hanazono-cho, Hirakata, Osaka 573-1121, Japan
Osaka Research Institute of Industrial Science and Technology, Morinomiya Center, 1-6-50, Morinomiya, Joto-ku, Osaka 536-8553, Japan
Department of Japan, Faculty of Health Sciences, Osaka Dental University, 1-4-4, Makino-honmachi, Hirakata-shi, Osaka 573-1121, Japan
Department of Advanced Hard Materials, The Institute of Scientific and Industrial Research (ISIR), Osaka University, Osaka 567-0047, Japan
Author to whom correspondence should be addressed.
Materials 2020, 13(12), 2772;
Received: 26 April 2020 / Revised: 8 June 2020 / Accepted: 15 June 2020 / Published: 18 June 2020
(This article belongs to the Special Issue The Application of Nano-Modified Titanium)
Nanostructured zirconia/alumina composite (NANOZR) has been explored as a suitable material for fabricating implants for patients with metal allergy. In this study, we examined the effect of UV treatment on the NANOZR surface. The experimental group was UV-treated NANOZR and the control group was untreated NANOZR. Observation of the surface of the UV-treated materials revealed no mechanical or structural change; however, the carbon content on the material surface was reduced, and the material surface displayed superhydrophilicity. Further, the effects of the UV-induced superhydrophilic properties of NANOZR plates on the adhesion behavior of various cells were investigated. Treatment of the NANOZR surface was found to facilitate protein adsorption onto it. An in vitro evaluation using rat bone marrow cells, human vascular endothelial cells, and rat periodontal ligament cells revealed high levels of adhesion in the experimental group. In addition, it was clarified that the NANOZR surface forms active oxygen and suppresses the generation of oxidative stress. Overall, the study results suggested that UV-treated NANOZR is useful as a new ceramic implant material. View Full-Text
Keywords: NANOZR; UV treatment; implant; bone differentiation; angiogenesis; periodontal tissue regeneration NANOZR; UV treatment; implant; bone differentiation; angiogenesis; periodontal tissue regeneration
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Komasa, S.; Takao, S.; Yang, Y.; Zeng, Y.; Li, M.; Yan, S.; Zhang, H.; Komasa, C.; Kobayashi, Y.; Nishizaki, H.; Nishida, H.; Kusumoto, T.; Okazaki, J. Effects of UV Treatment on Ceria-Stabilized Zirconia/Alumina Nanocomposite (NANOZR). Materials 2020, 13, 2772.

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